Improvement in parameters of quality of life and uterine volume reduction after uterine fibroid embolization

Silva, Nathalia Almeida Cardoso da; Szejnfeld, Dênis; Klajner, Rafael Kogan; Mata, Marcos Vinicius Maia da; Aun, Ricardo; Belczak, Sérgio Quilici

doi:10.31744/einstein_journal/2020ao5458

Cited by 5 publications

(6 citation statements)

References 30 publications

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“…At present, the specific causes of UL are not completely clear. Age, bad living habits, obesity, and gynecological inflammation are all risk factors for UL [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Value of Body Mass Index and Waist-Hip Ratio in Clinicopathological Characteristics and Prognosis of Uterine Leiomyomata

Pan

Qin²,

Deng³

2021

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the relationship between body mass index (BMI) and waist-to-hip ratio (WHR) and clinicopathological characteristics and prognosis of uterine leiomyomata (UL). Methods. A retrospective analysis of the clinical data of 133 patients with UL admitted to our hospital from September 2018 to August 2019. According to the BMI standard, the patients were divided into the normal group (n = 32), the super-recombination group (n = 45), and the obesity group (n = 56). According to WHR, the patients were divided into the normal body group (n = 32) and the obesity body group (n = 101). The prognosis of all patients with UL at 3 months postoperatively was evaluated. The relationship between BMI patients and clinical characteristics in different groups was compared, and univariate analysis and multivariate logistic regression model were used to analyze the factors affecting the prognosis of UL patients. Results. The proportion of UL patients in the overweight/obese group was higher than that of the normal group, the proportion of the obese body group was higher than that of the normal body group, and the proportion of the good prognosis group was higher than that of the poor prognosis group ( P < 0.05 ). The difference between the overweight/obese group and the normal group and the obese body group and the normal body group was irregular vaginal bleeding, the number of tumors, and the diameter of the lesion ( P < 0.05 ), and the differences between the degenerations in the obese body group and the normal body group were statistically significant ( P < 0.05 ). Multivariate analysis showed that BMI, WHR, surgical method, and tumor location were all independent risk factors that affected the prognosis of the surgery ( P < 0.05 ). Conclusion. Elevated BMI and WHR can be accompanied by an increased risk of UL. Obesity is a risk factor for UL. Overweight/obese women are more clinically pathological than normal patients, and overweight/obese patients have worse surgical prognosis than normal patients. In order to reduce the prevalence of UL and improve the clinicopathological characteristics and prognosis of patients, clinically obese women should be instructed to use reasonable diet and exercise to control weight.

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“…At present, the specific causes of UL are not completely clear. Age, bad living habits, obesity, and gynecological inflammation are all risk factors for UL [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Value of Body Mass Index and Waist-Hip Ratio in Clinicopathological Characteristics and Prognosis of Uterine Leiomyomata

Pan

Qin²,

Deng³

2021

Evidence-Based Complementary and Alternative Medicine

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“…UAE plays an important role in the treatment of symptomatic fibroids in today’s clinical routine with numerous studies reporting the effectiveness and safety of this minimal-invasive approach [ 9 – 14 , 19 – 25 ]. Many of these studies have focused on the rate of hysterectomies, myomectomies, or re-embolization following UAE, as the need for re-intervention is considered an objective treatment failure.…”

Section: Discussionmentioning

confidence: 99%

“…Several short- and long-term studies have highlighted the effectiveness and safety of UAE in the reduction of clinical symptoms and improvement of Health-Related Quality of Life (HRQoL) [ 9 – 14 ]. Nevertheless, only few studies incorporated validated outcome measures for assessing short- and long-term changes in symptoms and HRQoL.…”

Section: Introductionmentioning

confidence: 99%

Short- and long-term evaluation of disease-specific symptoms and quality of life following uterine artery embolization of fibroids

et al. 2022

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Background The purpose of this study is to evaluate uterine artery embolization (UAE) for the management of symptomatic uterine leiomyomas regarding changes in quality of life after treatment in a large patient collective. This study retrospectively analyzed prospectively acquired standardized questionnaires of patients treated with UAE. Clinical success was evaluated before and after embolization. Patients were stratified into short- (≤ 7 months) and long-term (> 7 months) follow-up groups depending on the time of completion of the post-interventional questionnaire. Uterine leiomyomas were furthermore divided into small (< 10 cm) and large (≥ 10 cm) tumors based on the diameter of the dominant fibroid. Results A total of 245 patients were included into the final data analysis. The Kaplan–Meier analysis showed a cumulative clinical success rate of 75.8% after 70 months until the end of follow-up (9.9 years). All questionnaire subscales showed a highly significant clinical improvement from baseline to short- and long-term follow-up (p < 0.001). Patients with small fibroids showed a significantly better response to UAE in multiple subcategories of the questionnaire than patients with fibroids ≥ 10 cm who had a twofold higher probability of re-intervention in the Cox-regression model. Conclusions UAE is an effective treatment method for symptomatic fibroids that leads to quick relief of fibroid-related symptoms with marked improvement of quality of life and is associated with a low risk for re-interventions. Patients with small fibroids tend to show a better response to UAE compared to patients with large fibroids. Trial registration Charité institutional review board, EA4/167/20. Registered 27 November 2020—Retrospectively registered. https://ethikkommission.charite.de/

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“…Interessanterweise scheint die postinterventionelle Verbesserung der klinischen Symptomatik bzw. der gesundheitsbezogenen Lebensqualität jedoch nicht immer mit dem radiologisch erfassbaren Grad der Volumenabnahme der Myome zu korrelieren [47].…”

Section: Aktueller Stand Der Myombehandlung Mittels Uaeunclassified

Medical historical notes on myoma treatment by uterine artery embolization on the occasion of its introduction 30 years ago

Psilopatis

Fleckenstein

Gebauer

et al. 2023

Rofo

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Background Since its development, uterine artery embolization (UAE) for the treatment of symptomatic fibroids has become an established minimally invasive alternative to surgical myoma treatment. Currently, more than 25,000 myoma patients worldwide are likely to be treated with UAE annually. Method Thirty years ago, Jacques-Henri Ravina (b. 1930) and his Paris team first performed this therapy as a “substitute” for gynecologic surgery. We contacted him as part of the preparation of the present review. In addition, we performed a literature search with the aim of summarizing the current literature and data in addition to a historical account of the development of UAE. Results and Conclusion On the occasion of this anniversary, we would like to recall the interdisciplinary roots and some facets of the history of the development of this relatively young myoma treatment method. Key points Citation Format

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Improvement in parameters of quality of life and uterine volume reduction after uterine fibroid embolization

Abstract: Improvement in parameters of quality of life and uterine volume reduction after uterine fibroid embolization Melhora em parâmetros de qualidade de vida e redução do volume uterino após embolização de artérias uterinas

Cited by 5 publications

References 30 publications

Clinical Value of Body Mass Index and Waist-Hip Ratio in Clinicopathological Characteristics and Prognosis of Uterine Leiomyomata

Clinical Value of Body Mass Index and Waist-Hip Ratio in Clinicopathological Characteristics and Prognosis of Uterine Leiomyomata

Short- and long-term evaluation of disease-specific symptoms and quality of life following uterine artery embolization of fibroids

Medical historical notes on myoma treatment by uterine artery embolization on the occasion of its introduction 30 years ago

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