Improvement in the survival of patients with stage IV non-small-cell lung cancer: Experience in a single institutional 1995–2017

Takano, Natsuki; Ariyasu, Ryo; Koyama, Junji; Sonoda, Tomoaki; Saiki, Masafumi; Kawashima, Yasunaru; Oguri, Tomoyo; Hisakane, Kakeru; Uchibori, Ken; Nishikawa, Shingo; Kitazono, Satoru; Yanagitani, Noriko; Ohyanagi, Fumiyoshi; Horiike, Atsushi; Gemma, Akihiko; Nishio, Makoto

doi:10.1016/j.lungcan.2019.03.008

Cited by 38 publications

(34 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The number of cancer patients is increasing rapidly due to the aging population of Japan 1 . In addition, the survival of cancer patients has been extended with the recent development of new drugs to treat the disease 2 . As a result, orthopedic surgeons today have more opportunities to treat patients with bone metastases than ever before.…”

Section: Introductionmentioning

confidence: 99%

Association of Pedicle Sign Type with Clinical and Radiological Features in Patients with Symptomatic Spinal Metastases

et al. 2021

View full text Add to dashboard Cite

Background: Cancer diagnoses are increasing rapidly due to the aging population of Japan. Pedicle sign is a valuable radiographic indicator of metastases as the pedicle is the most commonly affected part of the vertebra upon radiographic assessment. However, few detailed studies examining the morphological features of pedicle signs have been performed. To improve the capacity of medical professionals to diagnose symptomatic spinal metastases, we retrospectively examined the morphological characteristics of pedicle signs and their relationship with clinical and radiological features. Methods: In total, 186 patients with symptomatic spinal metastases who visited our department between January 1, 2011, and December 31, 2017, were enrolled in the study. Pedicle sign was defined as a pedicle that had disappeared or had become obscured on an anteroposterior radiographic image. Radiographic images were evaluated for pedicles and other structures of the vertebrae. Clinical and other radiological features were compared among the types of pedicle signs identified. Results: Pedicle signs were classified according to whether they had completely disappeared (complete type, 26 patients), partially disappeared (partial type, 40 patients), or were obscured by the osteoblastic background (blastic type, 28 patients). The disappearance of the bone cortex in addition to the pedicle was observed in almost half of the patients with complete and partial types of pedicle signs. Complete types were associated with significantly longer survival rates. Conclusion: Understanding of the various types of pedicle sign is required to properly diagnose bone metastases.

show abstract

Section: Introductionmentioning

confidence: 99%

Association of Pedicle Sign Type with Clinical and Radiological Features in Patients with Symptomatic Spinal Metastases

et al. 2021

View full text Add to dashboard Cite

show abstract

“…NSCLC is usually symptomatic and is therefore diagnosed at an advanced stage. Despite recent advancement in therapies, the prognosis of NSCLC patients remains unsatisfactory with a five‐ or 10‐year survival rate of 15%–20% of the total population without EGFR gene mutation or ALK translocation 7 …”

Section: Introductionmentioning

confidence: 99%

Expression and role of p16 and GLUT1 in malignant diseases and lung cancer: A review

Pezzuto

D’Ascanio²,

Rícci³

et al. 2020

Thoracic Cancer

View full text Add to dashboard Cite

Non‐small cell lung cancer (NSCLC) is the leading cause of cancer death and in most cases it is often diagnosed at an advanced stage. Many genetic and microenvironmental factors are able to modify the cell cycle inducing carcinogenesis and tumor growth. Among the metabolic and genetic factors that come into play in carcinogenesis and tumor cell differentiation and growth there are two different proteins that should be considered which are glucose transporters (GLUTs) and p16 INK4 The first are glucose transporters which are strongly involved in tumor metabolism, notably accelerating cancer cell metabolism both in aerobic and anaerobic conditions. There are different subtypes of GLUT family factors of which GLUT 1 is the most important and widely expressed. By contrast, p16 is mainly a tumor‐suppressor protein that acts on cyclin‐dependent kinase favoring cell cycle arrest in the G1 phase. Our search focused on the action of the aforementioned factors.

show abstract

“…The recent development of molecular targeted drugs and immune checkpoint inhibitors has significantly improved lung cancer treatment options and outcomes. 1 If patients with lung cancer are willing and able to work, physicians should respect this option. Moreover, in anticipation of an aging society and therefore a decline in the working population, securing able workers becomes increasingly important.…”

Section: Introductionmentioning

confidence: 99%

Importance of doctor‐initiated management of the balance between work and treatment for lung cancer patients: Results of a nationwide survey by the Japan Lung Cancer Society

et al. 2020

View full text Add to dashboard Cite

Backgrounds Since the recent development of molecular targeted drugs and immune checkpoint inhibitors has improved lung cancer treatment options and outcomes, supporting patients in balancing work and pharmacotherapy have become even more important in the field of lung cancer treatment. This study sought to identify the current status and roles of doctors in balancing work and treatment for lung cancer patients. Methods Patients and doctors were recruited to complete a web‐based questionnaire survey by the Japan Lung Cancer Society. Results About 287 lung cancer patients and 381 doctors were included in the analysis. About 42.9% of patients responded that “there was no discussion” about their working conditions or work before the initiation of pharmacotherapy, while 22.6% responded that “there was an inquiry from a doctor/health care provider and a discussion that included the doctor was held.” About 45.3% of patients took leave or resigned from work at the time of diagnosis. The most common reasons for patients to resign before or during pharmacotherapy were “poor physical condition due to side effects of treatment or illness” and “concern about causing problems in the workplace.” To assist in balancing work and pharmacotherapy, patients desired “increased opportunities to consult about work” (36.9%) and “provision of treatment options with few adverse events” (28.9%). Conclusion This study highlights the importance of doctor‐initiated management of the balance between work and treatment for lung cancer patients. An important first step is for doctors themselves to take an interest in their patients' professions and initiate discussions of work‐related topics with their patients.

show abstract

Improvement in the survival of patients with stage IV non-small-cell lung cancer: Experience in a single institutional 1995–2017

Cited by 38 publications

References 24 publications

Association of Pedicle Sign Type with Clinical and Radiological Features in Patients with Symptomatic Spinal Metastases

Association of Pedicle Sign Type with Clinical and Radiological Features in Patients with Symptomatic Spinal Metastases

Expression and role of p16 and GLUT1 in malignant diseases and lung cancer: A review

Importance of doctor‐initiated management of the balance between work and treatment for lung cancer patients: Results of a nationwide survey by the Japan Lung Cancer Society

Contact Info

Product

Resources

About