Improvement of cell attachment capabilities of poly-l-lactic acid films by modification of surface properties with ion-beam irradiation

Tanaka, Toŝhiyuki; Suzuki, Y.; Tsuchiya, Koji; Yajima, Hirofumi

doi:10.1016/j.surfcoat.2012.12.047

Cited by 8 publications

(4 citation statements)

References 27 publications

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“…By tuning the FIB irradiation conditions to avoid thermal deformation and debris, we obtained fine patterns such as φ80-nm-through-holes and 60-nm-wide lines. Moreover, the surfaces of these micro/nanostructures of the PLLA have a controlled amount of C=C, which influences the cell attachment [30]. Micro-fabricated PLLAs by FIB direct etching are advanced micro/nanodevices applicable especially in the biology and medicine fields.…”

Section: Intensity (Arbunit)mentioning

confidence: 99%

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Development of Advanced Biodevices Using Quantum Beam Microfabrication Technology

Oyama

Kimura

Nagasawa

et al. 2020

QuBS

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Biodevices with engineered micro- and nanostructures are strongly needed for advancements in medical technology such as regenerative medicine, drug discovery, diagnostic reagents, and drug delivery to secure high quality of life. The authors produced functional biocompatible plastics and hydrogels with physical and chemical properties and surface microscopic shapes that can be freely controlled in three dimensions during the production process using the superior properties of quantum beams. Nanostructures on a biocompatible poly(L-lactic acid) surface were fabricated using a focused ion beam. Soft hydrogels based on polysaccharides were micro-fabricated using a focused proton beam. Gelatin hydrogels were fabricated using γ-rays and electron beam, and their microstructures and stiffnesses were controlled for biological applications. HeLa cells proliferated three-dimensionally on the radiation-crosslinked gelatin hydrogels and, furthermore, their shapes can be controlled by the micro-fabricated surface of the hydrogel. Long-lasting hydrophilic concave structures were fabricated on the surface of silicone by radiation-induced crosslinking and oxidation. The demonstrated advanced biodevices have potential applications in three-dimensional cell culture, gene expression control, stem cell differentiation induction/suppression, cell aggregation into arbitrary shapes, tissue culture, and individual diagnosis in the medical field.

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Section: Intensity (Arbunit)mentioning

confidence: 99%

“…The damage cascade and energy deposition of FIB can be simulated using SRIM/TRIM code [29]. Additionally, PLLA surfaces should have a controlled amount of C=C, which influences the cell attachment [30].…”

Section: Introductionmentioning

confidence: 99%

Development of Advanced Biodevices Using Quantum Beam Microfabrication Technology

Oyama

Kimura

Nagasawa

et al. 2020

QuBS

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“…This method can dynamically control both the pore formation process and the morphology of the resultant pores. 18 Tanaka et al 19 successfully prepared pit-patterned surfaces of polystyrene (PS) films by liquid-induced phase separation. Then, the corresponding scale island-patterned poly(L-lactide) surfaces were prepared using the pit-patterned PS films as template.…”

Section: Introductionmentioning

confidence: 99%

Micropatterned fabrication of chitosan-based thermoresponsive membranes for improving cell adhesion and gene expression

Zhao

et al. 2016

Journal of Bioactive and Compatible Polymers

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A simple, rapid, and economical method to fabricate micropatterned thermoresponsive chitosan membranes was developed. Porous polystyrene films were prepared by liquid-induced phase separation. The size of pores on polystyrene films could be regulated by adjusting the composition of coagulation bath and changing the solvent evaporation rate. Subsequently, chitosan-based thermoresponsive membranes with island protrusions were fabricated using porous polystyrene films as templates. The effects of the micropatterns on the behaviors of mouse fibroblast L929 were investigated. The presence of micropatterns altered the cell cycle distribution and enhanced the gene expression of cyclin D1 and integrin β1. The micro-convex surface could promote the adhesion and proliferation of L929 cells. These results provided valuable guidance to design appropriate topographic surfaces for tissue engineering applications.

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“…In order to achieve a higher attached cell density and to promote cell culture on biomedical materials, many studies have been reported to modify these biodegradable polymers using various approaches [14][15][16][17][18]. In particular, ion irradiation at different energies is an effective method used to provide specific surface properties in different polymer materials [19] and, in recent years, in PLLA [20,21]. The ion beam irradiation method modifies the surface characteristic and induces a more hydrophilic surface, without changing the degradation properties of PLLA [22].…”

Section: Introductionmentioning

confidence: 99%

Studies of endothelial monolayer formation on irradiated poly-l-lactide acid with ions of different stopping power and velocity

Arbeitman

Grosso

Ibañez

et al. 2015

Nuclear Instruments and Methods in Physics Research Section B:

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Improvement of cell attachment capabilities of poly-l-lactic acid films by modification of surface properties with ion-beam irradiation

Cited by 8 publications

References 27 publications

Development of Advanced Biodevices Using Quantum Beam Microfabrication Technology

Development of Advanced Biodevices Using Quantum Beam Microfabrication Technology

Micropatterned fabrication of chitosan-based thermoresponsive membranes for improving cell adhesion and gene expression

Studies of endothelial monolayer formation on irradiated poly-l-lactide acid with ions of different stopping power and velocity

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