Improvement of Cognitive Function by Wasabi Component “Hexaraphane”

Abstract

Hexaraphane (6-methylsulfinylhexyl isothiocyanate; 6-MSITC) is an isothiocyanate present in the rhizomes and roots of wasabi (Eutrema japonicum (Miq.) Kiudz.). It is known to induce detoxifying and antioxidant enzymes by activating the Keap1-Nrf2 system, ameliorating oxidative damage in the body. Hexaraphane was shown to inhibit brain damage and improve dementia symptoms in Alzheimer’s model mice. Moreover, in two randomized controlled trials conducted on middle-aged and elderly subjects, the extract powder “Wasabi sulfinyl™” containing 0.8% hexaraphane improved memory, attention, and judgment. In a clinical study of fifteen patients with chronic fatigue syndrome, treatment with Wasabi sulfinyl ™ for 3 months improved brain fog and other symptoms.