Improvement of cognitive function in mice by Citrus reticulata var. kinnow via modulation of central cholinergic system and oxidative stress

Pruthi, Simran; Kaur, Karanpreet; Singh, Varinder; Shri, Richa

doi:10.1007/s11011-021-00687-7

Cited by 10 publications

(1 citation statement)

References 49 publications

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“…Therefore, PGEO attenuates SCOP-induced oxidative stress, demonstrating a protective effect, and has no adverse effects on oxidative status in native zebrafish. The antioxidant effects of Citrus essential oils on the brains of laboratory animals have been previously reported in multiple studies [ 69 , 70 , 71 , 72 , 73 ].…”

Section: Resultsmentioning

confidence: 99%

Investigating the Potential of Essential Oils from Citrus reticulata Leaves in Mitigating Memory Decline and Oxidative Stress in the Scopolamine-Treated Zebrafish Model

Brinza,

Boiangiu,

Honceriu

et al. 2024

Plants

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Petitgrain essential oil (PGEO) is derived from the water distillation process on mandarin (Citrus reticulata) leaves. The chemical constituents of PGEO were analyzed by gas chromatography/mass spectrometry (GC/MS) method which revealed the presence of six compounds (100%). The major peaks were for methyl-N-methyl anthranilate (89.93%) and γ-terpinene (6.25%). Over 19 days, zebrafish (Tubingen strain) received PGEO (25, 150, and 300 μL/L) before induction of cognitive impairment with scopolamine immersion (SCOP, 100 μM). Anxiety-like behavior and memory of the zebrafish were assessed by a novel tank diving test (NTT), Y-maze test, and novel object recognition test (NOR). Additionally, the activity of acetylcholinesterase (AChE) and the extent of the brain’s oxidative stress were explored. In conjunction, in silico forecasts were used to determine the pharmacokinetic properties of the principal compounds discovered in PGEO, employing platforms such as SwissADME, Molininspiration, and pKCSM. The findings provided evidence that PGEO possesses the capability to enhance memory by AChE inhibition, alleviate SCOP-induced anxiety during behavioral tasks, and diminish brain oxidative stress.

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