Improvement of the diuretic effect of triamterene via solid dispersion technique with PEG 4000

Abstract

The present investigation was designed and undertaken in order to substantiate further contention concerning the universality of the utilization of PEG polymers as matrix carriers. This study could then be considered an attempt to enhance the dissolution rate of triamterene, with the subsequent enhancement in its absorption rate, via solid dispersion using PEG 4000. The approach of solid dispersions was found useful for optimizing the pharmacokinetic of triamterene in rats.

Anomalous properties of spray dried solid dispersions

“…Solid dispersions are largely amorphous mixtures of the active pharmaceutical ingredient (API) and polymeric excipients. Many poorly soluble APIs exist and there is potential that amorphous solid dispersions could display better dissolution profiles1, 2 than the crystalline API. A wide range of processes can be used to prepare amorphous solid dispersions including melt extrusion and spray drying.…”