2013
DOI: 10.1093/schbul/sbt057
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Improvements in Negative Symptoms and Functional Outcome After a New Generation Cognitive Remediation Program: A Randomized Controlled Trial

Abstract: Cognitive remediation improves cognition in patients with schizophrenia, but its effect on other relevant factors such as negative symptoms and functional outcome has not been extensively studied. In this hospital-based study, 84 inpatients with chronic schizophrenia were recruited from Alava Hospital (Spain). All of the subjects underwent a baseline and a 3-month assessment that examined neurocognition, clinical symptoms, insight, and functional outcome according to the Global Assessment of Functioning (GAF) … Show more

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Cited by 67 publications
(72 citation statements)
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“…In addition to cognitive behavioral therapy to address apathy in schizophrenia, cognitive remediation therapy could be applied to target diminished expression. Until now, cognitive remediation has been found in some but not all studies to improve overall negative symptoms (Dickinson et al, 2010;Sánchez et al, 2014). Our findings clearly suggest that apathy and diminished expression need to be addressed as separate outcomes in order to clarify the effect of cognitive remediation on negative symptoms.…”
Section: Discussionmentioning
confidence: 66%
“…In addition to cognitive behavioral therapy to address apathy in schizophrenia, cognitive remediation therapy could be applied to target diminished expression. Until now, cognitive remediation has been found in some but not all studies to improve overall negative symptoms (Dickinson et al, 2010;Sánchez et al, 2014). Our findings clearly suggest that apathy and diminished expression need to be addressed as separate outcomes in order to clarify the effect of cognitive remediation on negative symptoms.…”
Section: Discussionmentioning
confidence: 66%
“…That said, treatments that are aimed at enhancing one domain, say cognition, should concurrently assess the effects on amotivation/negative symptoms. There is some evidence, for example, that interventions aimed at enhancing cognitive function improve functional outcome, which is more closely related to secondary improvement in negative symptoms rather than cognition per se (62,63). It will be an important area of research to examine whether either amotivation or neurocognitive deficits are necessary or sufficient for poor functioning among individuals with schizophrenia.…”
Section: Discussionmentioning
confidence: 99%
“…27 From a clinical perspective, our results support the use of cognitive remediation (CR) as an effective psychological intervention for treating apathy in schizophrenia patients. However if some studies have shown the effectiveness of CR to reduce negative symptoms, 63,64 most of the therapies designed to enhance cognition do not seem to be effective in improving negative symptoms. 65 This apparent contradiction can be partly explained by differences in study design.…”
Section: Discussionmentioning
confidence: 99%