Improvements in the detection and characterization of engineered nanoparticles using spICP-MS with microsecond dwell times

Montaño, Manuel D.; Badiei, Hamid R.; Bazargan, S.; Ranville, James F.

doi:10.1039/c4en00058g

Cited by 128 publications

(141 citation statements)

References 42 publications

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“…Although SP-ICP-MS shows a great potential for NP analysis, the presence of dissolved species of the monitored element can hinder or even make impossible the detection of the NPs. This limitation may be overcome with the last generation of ICP-MS instruments, capable of working with data acquisition frequencies up to 10 5 Hz and reading times in the microsecond range [120]. On the other hand, physical…”

Section: Single Particle Icp-msmentioning

confidence: 99%

Detection, characterization and quantification of inorganic engineered nanomaterials: A review of techniques and methodological approaches for the analysis of complex samples

Laborda

Bolea

Cepriá

et al. 2016

Analytica Chimica Acta

331

170

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The increasing demand of analytical information related to inorganic engineered nanomaterials requires the adaptation of existing techniques and methods, or the development of new ones.The challenge for the analytical sciences has been to consider the nanoparticles as a new sort of analytes, involving both chemical (composition, mass and number concentration) and physical information (e.g. size, shape, aggregation). Moreover, information about the species derived from the nanoparticles themselves and their transformations must also be supplied. Whereas techniques commonly used for nanoparticle characterization, such as light scattering techniques, show serious limitations when applied to complex samples, other well-established techniques, like electron microscopy and atomic spectrometry, can provide useful information in most cases. Furthermore, separation techniques, including flow field flow fractionation, capillary electrophoresis and hydrodynamic chromatography, are moving to the nano domain, mostly hyphenated to inductively coupled plasma mass spectrometry as element specific detector.Emerging techniques based on the detection of single nanoparticles by using ICP-MS, but also coulometry, are in their way to gain a position. Chemical sensors selective to nanoparticles are in their early stages, but they are very promising considering their portability and simplicity.Although the field is in continuous evolution, at this moment it is moving from proofs-of-2 concept in simple matrices to methods dealing with matrices of higher complexity and relevant analyte concentrations. To achieve this goal, sample preparation methods are essential to manage such complex situations. Apart from size fractionation methods, matrix digestion, extraction and concentration methods capable of preserving the nature of the nanoparticles are being developed. This review presents and discusses the state-of-the-art analytical techniques and sample preparation methods suitable for dealing with complex samples. Single-and multimethod approaches applied to solve the nanometrological challenges posed by a variety of stakeholders are also presented.

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Section: Single Particle Icp-msmentioning

confidence: 99%

Detection, characterization and quantification of inorganic engineered nanomaterials: A review of techniques and methodological approaches for the analysis of complex samples

Laborda

Bolea

Cepriá

et al. 2016

Analytica Chimica Acta

331

170

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“…Semiconductors have significant hybrid materials for point of control diagnosis techniques that exploit large fabricated consumer devices that are preferred to bulky scientific instrumentation. As seen in Figure 8 (Petryayeva et al, 2014), quantitative and laminated FRET-based structures are shown with economic UV visible light sources as an illustrative example (Lyshevski, 2005;Gadegaard et al, 2006;Montano et al, 2014). Here, the QD structures allow detection of the broad and strong absorption ranges by utilization of a visible LED light for stimulation, which is acquired by the built-in visible color filters of the smartphone camera without noise.…”

Section: Hybrid Np Materialsmentioning

confidence: 99%

“…For example, aptamers within one QD can bind to the same target biomolecule (i.e. a protein with more than one homogeneous binding site) and might decrease the signal intensity (Mayoral et al, 1997;Lukianova-Hleb et al, 2012;Martinolich et al, 2012;Mkenzie et al, 2012;Monguzzi et al, 2014;Montano et al, 2014;Luo et al, 2015;Madden et al, 2015;Mahyad et al, 2015;Matea et al, 2015;Mishra et al, 2016).…”

Section: Semiconductor Quantum Dotsmentioning

confidence: 99%

Hybrid nanomaterial: biocolloidals

Gözübenli¹,

Yasun²,

Dilsiz³

2017

Turk J Biol

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Nanomaterials-based diagnostics have tremendous advantages over other conventional diagnostic systems in terms of sensitivity, specificity, and portability owing to the unique intrinsic properties of nanomaterials. Thus, there is a substantial need to develop and employ a broad spectrum of nanomaterials for biological and diagnostic applications. In this review, we focus on nanomaterials-assisted disease diagnosis utilizing different techniques such as photoluminescence, colorimetry, fluorescence, electrochemistry, microarray methods, surface plasmon resonance, and surface-enhanced Raman spectroscopy. In these techniques, different nanomaterials, including but not limited to gold and silver materials, metal oxides, and semiconductors, were employed according to their all-purpose chemical and physical properties. As the new properties of nanomaterials are discovered, their contributions to nanobiotechnology applications are vastly increased. In this review, the features of the selected nanobiomaterials, biological tag-modified nanomaterials, and their outstanding applications for the detection of specific biotargets have been summarized according to the latest studies. Nanomaterials contribute to the fields of photo/chemotherapy and biomedical imaging in particular, since all the biological events happen within this size range and beneficiary roles of nanoparticles (NPs) are countless in biomedical applications due to their unique physical and chemical properties. However, due to the necessity of specificity and selectivity, there is a clear ambition to study bioconjugation of NPs to increase the efficiency of the targeted biological applications. Thus, the combination of the specificity and the intrinsic properties of biohybrid NPs facilitate diagnostic and therapeutic applications.

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“…There is a tail in the PSD that disappeared upon spiking to the mesocosm. This tail thus most likely contained loose agglomerates that were re-dispersed upon spiking in the WWT liquor, because FAST spICP-MS has nearly no artefacts of double particle events, which in conventional spICP-MS could for the measured c p cause tails in the PSD at larger particle diameters [11][12] . It can be calculated that the corresponding spherical diameter of aggregates consisting of n particles each having diameter d equals n 1/3 d part .…”

mentioning

confidence: 99%

“…Moreover, FAST has a more extended linear range in terms of particle number concentration 11,12 than conventional spICPMS, because especially at higher concentrations, more than one ion cloud formed by particles can arrive at the detector during the long t dwell used in conventional spICP-MS.…”

mentioning

confidence: 99%

Size dependence of silver nanoparticle removal in a wastewater treatment plant mesocosm measured by FAST single particle ICP-MS

Tuoriniemi

Jürgens

Hassellöv

et al. 2017

Environ. Sci.: Nano

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The quantities of engineered nanoparticles (NP) released to the environment are often influenced by their fate in waste water treatment plants (WWTP). Here, 40 nm silver NP (AgNP) were spiked into a mesocosm simulating the process used at a major municipal WWTP. The evolution of the mass distributions and number concentrations were followed by fast acquisition speed technique single particle inductively coupled mass spectrometry (FAST spICP-MS) using a high-resolution ICP-MS. It was thus possible to detect smaller Ag containing NP than hitherto possible in similar studies. These small particles (ca. 5-10 nm in corresponding metallic Ag equivalent spherical diameter) were possibly dissolved Ag + precipitated as Ag 2 S particles. They were detected immediately upon spiking and were stable with respect to aggregation and thus much less removed by the WWTP process compared to the 40 nm AgNP. The results also suggested that any transformation of the latter AgNP occurred without dissolution. Most of these larger AgNP were probably removed by aggregation with large floc particles and subsequent sedimentation with the suspended particulate matter in the simulated WWTP process. The results have implications for differentiating the fate of nanoparticles as a function of size and demonstrate how spICP-MS can reveal such size-dependent fate dynamics. Environmental Significance StatementThe size distributions of Ag nanoparticles during simulated waste water treatment were followed by FAST spICP-MS. The high sensitivity allowed to detect particles with an Ag mass as small as ca. 5 nm in corresponding metallic Ag equivalent spherical diameter. These small particles were contrary to expectations stable with respect to aggregation with suspended particulate matter.

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Improvements in the detection and characterization of engineered nanoparticles using spICP-MS with microsecond dwell times

Abstract: The utilization of microsecond dwell times allows for the detection of multiple elements within a single particle.

Cited by 128 publications

References 42 publications

Detection, characterization and quantification of inorganic engineered nanomaterials: A review of techniques and methodological approaches for the analysis of complex samples

Detection, characterization and quantification of inorganic engineered nanomaterials: A review of techniques and methodological approaches for the analysis of complex samples

Hybrid nanomaterial: biocolloidals

Size dependence of silver nanoparticle removal in a wastewater treatment plant mesocosm measured by FAST single particle ICP-MS

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