2021
DOI: 10.3390/pharmaceutics13101715
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Improving Curcumin Bioavailability: Current Strategies and Future Perspectives

Abstract: Curcumin possesses a plethora of interesting pharmacological effects. Unfortunately, it is also characterized by problematic drug delivery and scarce bioavailability, representing the main problem related to the use of this compound. Poor absorption, fast metabolism, and rapid systemic clearance are the most important factors contributing to low curcumin levels in plasma and tissues. Accordingly, to overcome these issues, numerous strategies have been proposed and are investigated in this article. Due to advan… Show more

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Cited by 149 publications
(94 citation statements)
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References 169 publications
(270 reference statements)
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“…Although curcumin is recognized as an active ingredient of turmeric and exhibits many beneficial effects for human diseases, its potential for nutraceutical and pharmaceutical applications is limited by its poor bioavailability [25]. The chemical instability, low absorption, extensive metabolism, and rapid elimination contributes to the poor bioavailability of curcumin [25,26]. In contrast, evidence shows THC displays better bioavailability than curcumin.…”
Section: Discussionmentioning
confidence: 99%
“…Although curcumin is recognized as an active ingredient of turmeric and exhibits many beneficial effects for human diseases, its potential for nutraceutical and pharmaceutical applications is limited by its poor bioavailability [25]. The chemical instability, low absorption, extensive metabolism, and rapid elimination contributes to the poor bioavailability of curcumin [25,26]. In contrast, evidence shows THC displays better bioavailability than curcumin.…”
Section: Discussionmentioning
confidence: 99%
“…However, it is important to note that the low oral bioavailability of curcumin has been of great concern [ 101 ]. For this reason, different strategies have been explored in vitro and in vivo to overcome this drawback, such us complexed/encapsulated curcumin, curcumin formulations, curcumin nanoparticles and the use of adjuvants that interferes with curcumin metabolism [ 102 ].…”
Section: Literature Searchmentioning
confidence: 99%
“…In our study, curcumin is the only compound that both can influence cisplatin and oxaliplatin-induced peripheral neurotoxicity. Unfortunately, it is also characterized by the lack of bioavailability and problematic drug delivery, representing a series of obstacles related to the use of this compound ( Tabanelli et al, 2021 ).…”
Section: Plant-derived Medicines Limiting Platinum-induced Peripheral Neurotoxicitymentioning
confidence: 99%