“…The included studies were conducted between 1988 and 2013. Thirty-five studies (53%) were parallel-group patient RCTs enrolling 237,025 patients 59,[61][62][63]71,72,75,80,82,[85][86][87][88][89]95,96,98,99,102,103,[107][108][109][111][112][113][114][115][116][117][118][119][120][121][122] and 31 (47%) were cluster RCTs in which the HCP or the health-care setting was the unit of randomisation. 58,60,64-70, 73,74,76-79,81,83,84,90-94,97,100,101,104-106,110,123 These included 6126 clusters (range 6-4125 clusters).…”