Improving exposure of anodically ordered Ni–Ti–O and corrosion resistance and biological properties of NiTi alloys by substrate electropolishing

Sun, Yonghua; Zhao, Ya; Zhao, Yuyu; Rong, Youjie; Yao, Runhua; Yao, Xiaohong; Hang, Ruiqiang; Chu, Paul K.

doi:10.1007/s12598-021-01721-4

Cited by 21 publications

(9 citation statements)

References 53 publications

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“…As for osteoblasts, our latest experiments show macrophage-derived exosomes have little influence on their integrin β1 trafficking (data not shown), so the promotion of growth factors on the proliferation may over the inhibition of proliferation by the exosomes. Differentiation determines the osteogenic and angiogenic activities [36]. ALP activity, type I collagen secretion, and ECM mineralization of osteoblasts were upregulated after incubation with the conditioned medium of macrophages (figure 12).…”

Section: Discussionmentioning

confidence: 99%

Resveratrol promotes osteogenesis and angiogenesis through mediating immunology of senescent macrophages

Hang¹,

Wang²,

Tian³

et al. 2022

Biomed. Mater.

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Orthopedic implants have been used clinically to restore the functions of the compromised bone tissues, but there is still a relatively high risk of failure for elderly people. A critical reason is pro-inflammatory immune microenvironment created by senescent macrophages with homeostasis imbalance impairs osteogenesis and angiogenesis, two major processes involved in implant osseointegration. The present work proposes to use resveratrol as an autophagy inducing agent to upregulate the autophagy level of senescent macrophages to restore homeostasis, consequently generating a favorable immune microenvironment. The results show 0.1-1 µM of resveratrol can induce autophagy of senescent macrophages, promote cell viability and proliferation, reduce intracellular reactive oxygen species (ROS) level, and polarize the cells to pro-healing M2 phenotype. The immune microenvironment created by senescent macrophages upon resveratrol stimulation can promote osteogenesis and angiogenesis, as manifested by upregulated proliferation, alkaline phosphatase activity, type I collagen secretion, and extracellular matrix mineralization of senescent osteoblasts as well as nitric oxide production, migration, and in vitro angiogenesis of senescent endothelial cells. In addition, resveratrol-loaded silk fibroin coatings can be fabricated on titanium surface through electrophoretic co-deposition and the coatings show beneficial effects on the functions of senescent macrophages. Our results suggest resveratrol can be used as surface additive of titanium implants to promote osseointegration of elderly people though regulating immunology of senescent macrophages.

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Section: Discussionmentioning

confidence: 99%

Resveratrol promotes osteogenesis and angiogenesis through mediating immunology of senescent macrophages

Hang¹,

Wang²,

Tian³

et al. 2022

Biomed. Mater.

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show abstract

“…For example, exosomes derived from IL-4treated macrophages can deliver miR-5106 to BMSCs which can target salt-inducible kinase 2 and 3 to induce osteogenic differentiation of cells [29]. Metallic materials such as Ti-based alloys, Co-based alloys, stainless steels, and biodegradable zinc (Zn) and Mg alloys are the main implant materials [30,31]. and YAP/TAZ nuclear translocation [33].…”

Section: Discussionmentioning

confidence: 99%

Exosomes derived from magnesium ion—stimulated macrophages inhibit angiogenesis

Hang¹,

Xue²,

Qu³

et al. 2022

Biomed. Mater.

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Angiogenesis, an essential prerequisite to osteogenesis in bone repair and regeneration, can be mediated by immunoregulation of macrophages. Magnesium and its alloys are promising biodegradable bone implant materials and can affect immunoregulation of macrophages by the degradation products (magnesium ions. Nevertheless, the mechanism of macrophage-derived exosomes stimulated by Mg ions in immunoregulation is still not well understood. Herein, 10-50 mM magnesium ions are shown to inhibit the macrophage viability and proliferation in a dose-dependent manner, but a high concentration results in macrophage apoptosis. The exosomes secreted by macrophages from magnesium ion stimulation inhibit angiogenesis of endothelial cells, as manifested by the suppressed cell viability, proliferation, migration, and tube formation, which arise at least partially from exosome-mediated downregulation of endothelial nitric oxide and the vascular endothelial growth factor. The findings reported in this paper suggest that the bio-functionality of biodegradable magnesium alloys must be considered from the perspective of immunoregulation of macrophage-derived exosomes. Our results also suggest potential cancer therapy by inhibiting tumor-associated angiogenesis.

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“…The physical, chemical, and mechanical properties of Ti surfaces affect the rate and quality of osseointegration, [3][4][5] and various surface technologies have been developed. However, as the safety and reliability of newly developed implants need to be fully assessed prior to clinical application, 6 the translation of technological innovation is generally slow.…”

Section: Introductionmentioning

confidence: 99%

Micro/nano-modified titanium surfaces accelerate osseointegration via Rab7-dependent mitophagy

Tang

Deng

et al. 2023

Biomater. Sci.

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Improving exposure of anodically ordered Ni–Ti–O and corrosion resistance and biological properties of NiTi alloys by substrate electropolishing

Cited by 21 publications

References 53 publications

Resveratrol promotes osteogenesis and angiogenesis through mediating immunology of senescent macrophages

Resveratrol promotes osteogenesis and angiogenesis through mediating immunology of senescent macrophages

Exosomes derived from magnesium ion—stimulated macrophages inhibit angiogenesis

Micro/nano-modified titanium surfaces accelerate osseointegration via Rab7-dependent mitophagy

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