Improving Glaucoma Surgical Outcomes with Adjunct Tools

Lu, Louise J.; Hall, Lynne A.

doi:10.5005/jp-journals-10028-1239

Cited by 18 publications

(10 citation statements)

References 130 publications

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“…Anterior scleral surgery in the form of trabeculectomy, scleral laser trabeculoplasty (SLT) and drainage shunt implantation has long been a clinical mainstay of IOP reduction in the treatment of medically uncontrolled glaucoma (Bovee and Pasquale, 2017), and here too techniques are progressing. The recent adoption of micro-pulse lasers for SLT (Yu et al, 2019), new shunt implant designs and materials (Chen and Gedde, 2018) and adjunct tools such as collagen matrix implants, fibrin adhesives, and amniotic membrane transplants (Lu et al, 2018) are all examples of emerging strategies to suppress fibrosis, scarring and other side-effects of glaucoma drainage surgery.…”

Section: Collateral Scleral Surgeriesmentioning

confidence: 99%

Scleral structure and biomechanics

Boote

Sigal

Grytz

et al. 2020

Progress in Retinal and Eye Research

208

161

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Collateral Scleral Surgeriesmentioning

confidence: 99%

Scleral structure and biomechanics

Boote

Sigal

Grytz

et al. 2020

Progress in Retinal and Eye Research

208

161

View full text Add to dashboard Cite

show abstract

“…However, these agents are non-selective and have been reported to induce severe damage by causing complications such as hypotony, corneal endothelial loss, and bleb-related endophthalmitis causing blindness [ 31 – 33 ]. Surgical interventions to reduce conjunctival scarring include the use of collagen-glycosaminoglycan implant, fibrin glue, and amniotic membrane transplantation [ 34 ]. A therapy for preventing conjunctival contraction and scarring during the wound healing process is often necessary.…”

Section: Discussionmentioning

confidence: 99%

Ahmed implant coated with poly(2-methacryloyloxyethyl phosphorylcholine) inhibits foreign body reactions in rabbit eyes

et al. 2021

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Purpose Wound healing after Ahmed glaucoma valve (AGV) implantation often entails fibrosis as a foreign body reaction to the silicone plate. Poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) forms an antifouling surface that inhibits fibrosis during wound healing. In this study, we aimed to compare the effects of the implantation of AGV coated with PMPC (wPMPC) versus AGV without PMPC (woPMPC) in rabbits. Methods Six New Zealand White rabbit does underwent AGV implantation in both eyes. For each rabbit, one eye was randomly selected for implantation of AGV wPMPC and a conventional AGV (woPMPC) was implanted in the contralateral eye. Gross conjunctival vascularity was compared between the two groups at the first, second, and fourth weeks after surgery. The eyes were enucleated in four weeks and subjected to staining with hematoxylin and eosin and Masson’s trichrome stain. The fibrosis and inflammation status among the eye samples were compared by measuring the thickness of the fibrotic walls and counting the number of chronic inflammatory cells around the AGV. Counting of inflammatory cells and measuring fibrotic wall thickness were done in a blinded method to eliminate observer bias. Statistical analysis was performed using the Mann-Whitney U test. Results Gross and histological examinations revealed no toxic effects of PMPC. There were no apparent differences in overall conjunctival vascularity between the two groups at weeks 1, 2, and 4 after surgery. The average inflammatory cell counts were 14.3 ± 5.8 per slide and 27.3 ± 8.6 per slide in the wPMPC and woPMPC groups, respectively (p = 0.037). The average thicknesses of the fibrotic wall were 57.9 ± 11.3 μm and 81.5 ± 21.3 μm in the wPMPC and woPMPC groups, respectively (p = 0.025). Conclusion Compared to the woPMPC group, the number of inflammatory cells and fibrosis were significantly decreased in the wPMPC group.

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“…Postoperatively, erythromycin (FDA class B) is administered both during pregnancy and lactation [28,50]. Trabeculectomy is an alternative for pregnant women in need of this intervention [41,51], which has been successful in decreasing intraocular pressure [21]. The use of antimetabolites (mitomycin C and 5-fluorouracil) is prohibited in pregnant patients [41].…”

Section: Surgical Treatment (Trabeculectomy)mentioning

confidence: 99%

A Narrative Review of the Complex Relationship between Pregnancy and Eye Changes

et al. 2021

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Pregnancy is a condition often characterized by changes that occur in different parts of the body. Generally, the eyes suffer several changes during pregnancy that are usually transient but may become permanent at times. This may occur due to the release of placental hormones and those of maternal endocrine glands and fetal adrenal glands. Due to hormonal influences, physiological ocular changes during pregnancy have been shown in Caucasian women, so corneal sensitivity, refractive status, intraocular pressure, and visual acuity may change during pregnancy. Within this review, all studies that referred to physiological aspects and to changes of ocular pathology of pregnancy, the effect of the pregnancy on pre-existing (diabetic retinopathy, neuro-ophthalmic disorders) eye disorders, postpartum ocular changes, the intraocular pressure and the effect of hypotensive ophthalmic medicine during pregnancy, the connection between pregnancy and the neuro-ophthalmic pathology, as well as the role of anesthesia were analyzed.

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Improving Glaucoma Surgical Outcomes with Adjunct Tools

Cited by 18 publications

References 130 publications

Scleral structure and biomechanics

Scleral structure and biomechanics

Ahmed implant coated with poly(2-methacryloyloxyethyl phosphorylcholine) inhibits foreign body reactions in rabbit eyes

A Narrative Review of the Complex Relationship between Pregnancy and Eye Changes

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