Improving melatonin circadian phase estimates

Someren, Eus J.W. Van; Nagtegaal, Elsbeth

doi:10.1016/j.sleep.2007.03.012

Cited by 67 publications

(56 citation statements)

References 25 publications

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“…differences in the steepness of the rising and falling limb [20]. The best fit was calculated using the Levenberg-Marquardt algorithm for nonlinear curve fitting included in SPSS for Windows (SPSS, Inc.).…”

Section: Methodsmentioning

confidence: 99%

Pituitary Hormone Secretion Profiles in IGSF1 Deficiency Syndrome

Joustra

Roelfsema²,

Endert³

et al. 2015

Neuroendocrinology

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Background: Loss-of-function mutations in immunoglobulin superfamily member 1 (IGSF1) cause an X-linked syndrome of central hypothyroidism, macroorchidism, delayed pubertal testosterone rise, variable prolactin deficiency and variable partial GH deficiency in childhood. The clinical features and gene expression pattern suggest a pivotal role for IGSF1 in the pituitary, but detailed knowledge on pituitary hormone secretion in this syndrome is lacking. We therefore aimed to study the 24-hour pituitary hormone secretion in male patients with IGSF1 deficiency. Methods: We collected blood samples every 10 min for 24 h in eight adult male IGSF1-deficient patients and measured circulating TSH, prolactin and gonadotropins. Deconvolution, modified cosinor and approximate entropy analyses were applied to quantify secretion rates, diurnal rhythmicity and regularity of hormone release. Results were compared to healthy controls matched for age and body mass index. Results: Compared to healthy controls, IGSF1-deficient patients showed decreased pulsatile secretion of TSH with decreased disorderliness and reduced diurnal variation. Basal and pulsatile secretion of FSH was increased by over 200%, while LH secretion did not differ from healthy controls. We observed a bimodal distribution of prolactin secretion, i.e. severe deficiency in three and increased basal and total secretion in the other five patients. Conclusion: The altered TSH secretion pattern is consistent with the previously hypothesized defect in thyrotropin-releasing hormone signaling in IGSF1 deficiency. However, the phenotype is more extensive and includes increased FSH secretion without altered LH secretion as well as either undetectable or increased prolactin secretion.

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Section: Methodsmentioning

confidence: 99%

Pituitary Hormone Secretion Profiles in IGSF1 Deficiency Syndrome

Joustra

Roelfsema²,

Endert³

et al. 2015

Neuroendocrinology

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“…Saliva was collected using Salivettes (Sarstedt, Nümbrecht, Germany) on two subsequent evenings (at 3, 2, and 1 h before and at habitual bedtime, and upon waking up spontaneously at night) and on the day in between (at awakening, 1 and 2 h after awakening, noon, and 3 p.m.) (13).…”

Section: Methodsmentioning

confidence: 99%

“…Melatonin data were fitted to a skewed baseline cosine function (SBCF, see 'Statistical analysis' section) (13). Altered melatonin secretion was defined as an absence of evening rise, daytime values O3 pg/ml, or severe irregularity in melatonin secretion, as indicated by non-fitting of the SBCF.…”

Section: Methodsmentioning

confidence: 99%

Alterations in diurnal rhythmicity in patients treated for nonfunctioning pituitary macroadenoma: a controlled study and literature review

Joustra

Thijs

Berg

et al. 2014

European Journal of Endocrinology

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Objective: Patients treated for nonfunctioning pituitary macroadenomas (NFMAs) have fatigue and alterations in sleep characteristics and sleep-wake rhythmicity frequently. As NFMAs often compress the optic chiasm, these complaints might be related to dysfunction of the adjacent suprachiasmatic nucleus (SCN). We aimed to explore whether indirect indices of SCN functioning are altered in the long term after surgery for NFMAs. Methods: We studied 17 NFMA patients in long-term remission after transsphenoidal surgery, receiving adequate and stable hormone replacement for hypopituitarism, and 17 control subjects matched for age, gender, and BMI. Indirect indices of SCN function were assessed from 24-h ambulatory recordings of skin and core body temperatures, blood pressure, and salivary melatonin levels. Altered melatonin secretion was defined as an absence of evening rise, considerable irregularity, or daytime values O3 pg/ml. We additionally studied eight patients treated for craniopharyngioma. Results: Distal-proximal skin temperature gradient did not differ between NFMAs and control subjects, but proximal skin temperature was decreased during daytime (PZ0.006). Core body temperature and non-dipping of blood pressure did not differ, whereas melatonin secretion was often altered in NFMAs (OR 5.3, 95% CI 0.9-30.6). One or more abnormal parameters (R2.0 SDS of control subjects) were observed during nighttime in 12 NFMA patients and during daytime in seven NFMA patients. Similar patterns were observed in craniopharyngioma patients. Conclusion: Heterogeneous patterns of altered diurnal rhythmicity in skin temperature and melatonin secretion parameters were observed in the majority of patients treated for NFMAs. On a group level, both NFMA and craniopharyngioma patients showed a lower daytime proximal skin temperature than control subjects, but other group averages were not significantly different. The observations suggest altered function of central (or peripheral) clock machinery, possibly by disturbed entrainment or damage of the hypothalamic SCN by the suprasellar macroadenoma or its treatment.

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“…The clock time of the minimum of the fitted curve was used as indicator of the phase of the 24-hour rhythm in core body temperature [30,31]. Correlations between time of body temperature minimum and DLMO as well as between renal function and melatonin, sleep and quality-of-life parameters were calculated with the Spearman's rank correlation coefficient.…”

Section: Methodsmentioning

confidence: 99%

The Effects of Kidney Transplantation on Sleep, Melatonin, Circadian Rhythm and Quality of Life in Kidney Transplant Recipients and Living Donors

Russcher

Nagtegaal²,

Nurmohamed³

et al. 2014

Nephron

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Background: Sleep disturbance is an important medical problem in patients with end-stage renal disease. It might be related to the disruption of the body's circadian clock since nocturnal levels of its key biomarker melatonin are markedly reduced. We aimed at investigating whether a change in renal function due to kidney transplantation or donation would modify sleep, melatonin levels, circadian rhythmicity, and quality of life in kidney transplant recipients (KTR) and living donors (LD). Methods: In KTR, we assessed saliva melatonin concentrations, sleep quality and daytime sleepiness prior to and at 2 weeks and 3 months after transplantation. In LD, we assessed these parameters prior to and at 3 months after donation. We additionally assessed 24-hour core body temperature (cBT), 24-hour blood pressure profile, and quality of life (QoL) prior to and 3 months after transplantation. Results: Twenty-three KTR and 23 LD completed the study. Regarding sleep, the amount of nighttime awake minutes tended to be reduced in recipients after transplantation (p = 0.05). Nocturnal melatonin concentrations did not change with transplantation or donation. Blood pressure dipping profile and the two circadian markers dim-light melatonin onset and time of core body temperature minimum did not change. Nevertheless, KTR reported that daytime sleepiness and QoL had improved. Conclusion: Objectively nocturnal sleep quality marginally improved after transplantation. Subjectively patients reported improved QoL and daytime sleepiness scores. Changes in renal function were not associated with modified melatonin secretion or circadian rhythmicity.

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Improving melatonin circadian phase estimates

Cited by 67 publications

References 25 publications

Pituitary Hormone Secretion Profiles in IGSF1 Deficiency Syndrome

Pituitary Hormone Secretion Profiles in IGSF1 Deficiency Syndrome

Alterations in diurnal rhythmicity in patients treated for nonfunctioning pituitary macroadenoma: a controlled study and literature review

The Effects of Kidney Transplantation on Sleep, Melatonin, Circadian Rhythm and Quality of Life in Kidney Transplant Recipients and Living Donors

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