Improving our understanding on the clinical role of plasmin-mediated von Willebrand factor degradation
Hinde El Otmani,
Karen Vanhoorelbeke,
Claudia Tersteeg
Abstract:Purpose of review
Von Willebrand factor (VWF) plays a pivotal role in primary hemostasis. A Disintegrin And Metalloproteinase with a ThromboSpondin type 1 motif, member 13 (ADAMTS13) is primarily responsible for cleaving ultra-large VWF multimers into smaller, less adhesive forms. However, plasmin has also been shown to cleave VWF multimers. This proteolytic cleavage of VWF results in a decreased multimer size and, hence, a lower VWF activity. This review aims to present a comprehensive overview of… Show more
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