Improving skills and institutional capacity to strengthen adolescent immunisation programmes and health systems in African countries through HPV vaccine introduction

Dochez, Carine; Burnett, Rosemary J.; Mbassi, Symplice Mbola; Were, Fred; Musyoki, Andrew Munyalo; Trovoada, Daisy; Mphahlele, M. Jeffrey

doi:10.1016/j.pvr.2017.08.003

Cited by 20 publications

(34 citation statements)

References 17 publications

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“…As of June 2018 there are eight countries in SSA with a national HPV immunisation program (see Table 2), and nearly twice as many with pilot programs [7,21]. Data on vaccine coverage in SSA countries with pilot or national programs is limited, and not available for all countries [5,19] (see Table 2).…”

Section: Hpv Vaccinationmentioning

confidence: 99%

“…As young girls are the target group for the vaccine, an appropriate delivery platform is required, and further barriers include sociocultural issues such as the stigmas associated with HPV being a sexually transmitted infection [21]. Lack of knowledge of HPV vaccination and associated misconceptions also make implementation challenging.…”

Section: Challenges In Implementing Hpv Vaccinationmentioning

confidence: 99%

“…Rwanda's national HPV vaccination program was planned with extensive input from a variety of stakeholders including the Ministry of Education (MOE) and health workers. A nationwide sensitisation campaign was rolled out before vaccinations began [6,22] (see Table 3), and the program was implemented without a prior demonstration project [21]. Schools were used as the delivery platform, which was effective as school attendance in Rwanda is greater than 98% [6].…”

Section: Rwanda's Experiencementioning

confidence: 99%

“…High levels of commitment at the national government level with demonstrated leadership are important for successful HPV introduction [21]. A recent collaborative project involving 17 SSA countries identified factors that facilitated successful HPV vaccination implementation.…”

Section: Government Ownership and Supportmentioning

confidence: 99%

“…A recent collaborative project involving 17 SSA countries identified factors that facilitated successful HPV vaccination implementation. Many of the participant countries reported that government support was critical for successful HPV introduction [21]. Government commitment and leadership was strengthened and exemplified through patronage of the first Ladies in a number of countries including South Africa, Mozambique, Tanzania and Rwanda.…”

Section: Government Ownership and Supportmentioning

confidence: 99%

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Prevention of Cervical Cancer in Sub-Saharan Africa: the Promises and Challenges of HPV Vaccination

Black¹,

Richmond²

2018

Preprint

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Abstract:In sub-Saharan Africa (SSA), cervical cancer is a critical public health issue; it is the second leading cause of cancer among women and the leading cause of female cancer deaths. Incidence and mortality rates are substantially higher than in high-income countries with population-based screening programs, yet implementing screening programs in SSA has so far proven to be challenging due to financial, logistical and sociocultural factors. Human Papillomavirus (HPV) vaccination is an effective approach for primary prevention of cervical cancer and presents an opportunity to reduce the burden from cervical cancer in SSA. With a number of SSA countries now eligible for GAVI support for vaccine introduction, it is timely to consider the factors that impede and facilitate implementation of vaccine programs in SSA. This article reviews the epidemiological and clinical features of cervical cancer in SSA and describes the current status of HPV vaccine implementation in SSA countries. The review considers the challenges that will need to be addressed, and effective approaches to the design and implementation of HPV vaccination programs, using Rwanda as a case study. The review aims to provide suggestions and guidance to those involved in the development and implementation of HPV vaccination programs in SSA.

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Section: Hpv Vaccinationmentioning

confidence: 99%

Section: Challenges In Implementing Hpv Vaccinationmentioning

confidence: 99%

Section: Rwanda's Experiencementioning

confidence: 99%

Section: Government Ownership and Supportmentioning

confidence: 99%

Section: Government Ownership and Supportmentioning

confidence: 99%

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Prevention of Cervical Cancer in Sub-Saharan Africa: the Promises and Challenges of HPV Vaccination

Black¹,

Richmond²

2018

Preprint

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Acting on the call: A framework for action for rapid acceleration of access to the HPV vaccination in low‐ and lower‐middle‐income countries

Kumar

Khanduri

Sidibe

et al. 2020

Intl J Gynecology & Obste

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Cervical cancer, caused by HPV infection, is responsible for more than 311 000 preventable deaths every year. A global call to accelerate efforts to eliminate this disease has generated a new global strategy proposing ambitious, but achievable, targets for HPV vaccination of girls, and screening and treatment of women. The present paper addresses the suboptimal access to HPV vaccination in low-income and lower-middleincome countries (LICs/LMICs), where the burden of disease weighs most heavily, in part through co-infection with HIV. A proposed framework for action was formulated by first reviewing the reasons underlying gaps in HPV vaccine coverage. Good practices from recent introductions of HPV vaccine at scale in LICs/LMICs were then assessed based on targeted literature reviews and the experience and views of the authors. Difficulties in uptake and coverage of the HPV vaccine relate to the costs of the vaccine and service delivery, lack of prioritization, the challenges of vaccinating adolescents, and shortage of vaccines as the supply failed to keep pace with the rapid expansion in global demand, including from LICs/LMICs. The framework for action calls for new strategic thinking to consolidate global learning and invigorate operationalization at a country level.

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Cervical cancer in Tanzania: A systematic review of current challenges in six domains

Runge

Bernstein

Lucas

et al. 2019

Gynecologic Oncology Reports

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Cervical cancer is the most common cancer in Tanzania. After excluding human immunodeficiency virus, lower respiratory infections, malaria, diarrheal diseases, and tuberculosis, cervical cancer kills more women than any other form of illness in the country. Unfortunately, Tanzania has a low doctor-to-patient ratio (1:50,000) and nearly 7000 women die each year from this disease. The clinical problem is further magnified by the country's lack of resources and prevailing poverty, sporadic cervical cancer screening, prevalence of high-risk oncogenic human papillomavirus subtypes, and relatively high rates of human immunodeficiency virus co-infection. In recent years, addressing the cervical cancer problem has become a priority for the Tanzanian government. In this systematic review of 39 peer-reviewed publications that appeared in the PubMed/MEDLINE (NCBI) database from 2013 to 2018, we synthesize the growing body of literature to capture current trends in Tanzania's evolving cervical cancer landscape. Six domains were identified, including risk factors, primary prevention, barriers to screening, treatment, healthcare worker education, and sustainability. In addition to traditional risk factors associated with sexual behavior, acetowhite changes observed during visual inspection of the cervix with acetic acid, lower education, rural setting, and HIV positivity also have a noteworthy clinical impact.

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Improving skills and institutional capacity to strengthen adolescent immunisation programmes and health systems in African countries through HPV vaccine introduction

Cited by 20 publications

References 17 publications

Prevention of Cervical Cancer in Sub-Saharan Africa: the Promises and Challenges of HPV Vaccination

Prevention of Cervical Cancer in Sub-Saharan Africa: the Promises and Challenges of HPV Vaccination

Acting on the call: A framework for action for rapid acceleration of access to the HPV vaccination in low‐ and lower‐middle‐income countries

Cervical cancer in Tanzania: A systematic review of current challenges in six domains

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