2022
DOI: 10.1002/crat.202200151
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Improving Solubility and Avoiding Hygroscopicity of Tetrahydropalmatine by Forming a Pharmaceutical Salt Cocrystal via CAHBs

Abstract: In order to improve the solubility of tetrahydropalmatine (THP), an unreported THP‐sulfosalicylic acid (THP‐SSA) pharmaceutical salt cocrystal is designed and synthesized. Structural analysis shows that the building unit of THP‐SSA is composed of two THP cations, two SSA anions and one ethyl acetate molecule. Meanwhile, 1D chain, 2D layered structure, 3D hydrogen bond network, and Supramolecular motif R1110(48) of THP‐SSA are connected by stable charge‐assisted hydrogen bonds (CAHBs) N+‐H···O‐, π–π packing, an… Show more

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Cited by 2 publications
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