Improving the bioavailability and bioactivity of garlic bioactive compounds
            <i>via</i>
            nanotechnology

Lu, Xiaoming; Wang, Chaofan; Zhao, Meng; Wu, Jinxiang; Niu, Zhonglu; Zhang, Xueli; Simal-Gándara, Jesús; Süntar, İpek; Jafari, Seid Mahdi; Qiao, Xuguang; Tang, Xiaozhen; Han, Zhenlin; Xiao, Jianbo; Li, Ningyang

doi:10.1080/10408398.2021.1929058

Cited by 11 publications

(5 citation statements)

References 243 publications

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“…As an example, pyrethrin aerosol (23.4 g formulation/28 m 3 of headspace area) after 7 days from exposure caused a lower than 40% mortality rate against T. confusum, but this increased to almost 85% after 14 days [56]. The strong toxicity demonstrated by the EO-based nano-formulations can also be attributed to their nanometric scale that increases the bioavailability and bioactivity of the active components [57]. However, the exact mode of action of EOs against this target species has not been clarified yet, although previous studies demonstrated that monoterpenes could interfere with the octopaminergic system of the pests, resulting in damages to the nervous system [15,58].…”

Section: Discussionmentioning

confidence: 99%

Essential Oil-Based Nano-Biopesticides: Formulation and Bioactivity against the Confused Flour Beetle Tribolium confusum

et al. 2021

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Post-harvest pest control can rely on few approved pesticides and tools; hence, there is a rising interest in new sustainable, eco-friendly approaches. In this study, eight commercial essential oils (EOs) (anise Pimpinella anisum, artemisia Artemisia vulgaris, fennel Foenicum vulgare, garlic Allium sativum, lavender Lavandula angustifolia, mint Mentha piperita, rosemary Rosmarinus officinalis, and sage Salvia officinalis) were selected for their bioactivity and commercial availability, and then formulated in nano-emulsions. Repellency and acute toxicity of the developed nano-formulations were tested against a key stored product pest, Tribolium confusum (Coleoptera: Tenebrionidae). All the developed nano-emulsions presented optimal physical characteristics (droplet dimension = 95.01–144.30 nm; PDI = 0.146–0.248). All the formulations were repellent over time tested against adult beetles, in area preference bioassays. The best repellent was the anise EO-based formulation (RC50 = 0.033 mg). Mortality values from cold aerosol trials showed that the majority of tested EOs caused immediate acute toxicity, and garlic EO nano-emulsion caused the highest mortality of T. confusum adults (LC50 = 0.486 mg/L of air). EO-based nano-insecticides, used as cold aerosol and gel, are promising control methods against stored product pests, which can be integrated and combined with other sustainable biorational approaches.

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Section: Discussionmentioning

confidence: 99%

Essential Oil-Based Nano-Biopesticides: Formulation and Bioactivity against the Confused Flour Beetle Tribolium confusum

et al. 2021

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“…A number of studies have shown that nanoparticles have the potential to scale up the solubility and stability of phytochemical extracts ( Lawson and Gardner, 2005 ; Putnik et al, 2019 ). As a result, the use of nanotechnology with biological compounds has advantages in the utilization, which are considered as potential approaches ( Lu et al, 2022 ). Table 2 presents the research on the use of nanotechnology combined with biological compounds to treat tumors through ferroptosis.…”

Section: Nano-drug Delivery Strategy For Inducing Ferroptosis In Tumormentioning

confidence: 99%

Ferroptosis: emerging roles in lung cancer and potential implications in biological compounds

Liang,

Wang,

et al. 2024

Front. Pharmacol.

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Lung cancer has high metastasis and drug resistance. The prognosis of lung cancer patients is poor and the patients’ survival chances are easily neglected. Ferroptosis is a programmed cell death proposed in 2012, which differs from apoptosis, necrosis and autophagy. Ferroptosis is a novel type of regulated cell death which is driven by iron-dependent lipid peroxidation and subsequent plasma membrane ruptures. It has broad prospects in the field of tumor disease treatment. At present, multiple studies have shown that biological compounds can induce ferroptosis in lung cancer cells, which exhibits significant anti-cancer effects, and they have the advantages in high safety, minimal side effects, and less possibility to drug resistance. In this review, we summarize the biological compounds used for the treatment of lung cancer by focusing on ferroptosis and its mechanism. In addition, we systematically review the current research status of combining nanotechnology with biological compounds for tumor treatment, shed new light for targeting ferroptosis pathways and applying biological compounds-based therapies.

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“…Firstly, due to the unstable chemical properties and unpredictable bioavailability of allicin, further research is needed on purification processes and preparation methods to improve its stability and pharmacological activity. Recent advances in formulation strategies and nanotechnology-based drug delivery systems show promise in addressing these challenges, potentially improving allicin’s solubility, stability, and bioavailability [ 100 , 101 ]. Meanwhile, the targeting technology of nanoscale materials enabled the delivery of active ingredients to the desired action site in sufficient concentrations, enhancing their ability to get absorbed into cells.…”

Section: Limitations Of Clinical Applicationmentioning

confidence: 99%

Therapeutic potentials of allicin in cardiovascular disease: advances and future directions

Gao,

Wang,

Qin

et al. 2024

Chin Med

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Cardiovascular disease (CVD) remains the predominant cause of mortality and disability worldwide. Against this backdrop, finding effective drugs for the pharmacological treatment of CVD has become one of the most urgent and challenging issues in medical research. Garlic (Allium sativum L.) is one of the oldest plants and is world-renowned for its dietary and medicinal values. Allicin (diallyl thiosulfinate) is one of the primary natural active ingredients in garlic, which has been proven to have powerful cardioprotective effects and mediate various pathological processes related to CVD, such as inflammatory factor secretion, myocardial cell apoptosis, oxidative stress, and more. Therefore, allicin holds a promising application prospect in the treatment of CVD. This review summarized the biological functions of allicin and its potential mechanisms in CVD, including antioxidation, anti-inflammation, and anti-apoptosis effects. Reckoning with these, we delved into recent studies on allicin’s cardioprotective effects concerning various CVDs, such as atherosclerosis, hypertension, myocardial infarction, arrhythmia, cardiac hypertrophy, heart failure, and cardiotoxicity. Further, considering the tremendous advancement in nanomedicine, nanotechnology-based drug delivery systems show promise in addressing limitations of allicin’s clinical applications, including improving its solubility, stability, and bioavailability. Through this review, we hope to provide a reference for further research on allicin in cardioprotection and drug development. Graphical Abstract

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Improving the bioavailability and bioactivity of garlic bioactive compounds via nanotechnology

Cited by 11 publications

References 243 publications

Essential Oil-Based Nano-Biopesticides: Formulation and Bioactivity against the Confused Flour Beetle Tribolium confusum

Essential Oil-Based Nano-Biopesticides: Formulation and Bioactivity against the Confused Flour Beetle Tribolium confusum

Ferroptosis: emerging roles in lung cancer and potential implications in biological compounds

Therapeutic potentials of allicin in cardiovascular disease: advances and future directions

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