Improving the detection limits of antispasmodic drugs electrodes by using modified membrane sensors with inner solid contact

Ibrahim, Hossam; Issa, Y. M.; Shawish, Hazem M. Abu

doi:10.1016/j.jpba.2007.01.018

Cited by 44 publications

(28 citation statements)

References 26 publications

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“…16,17) These electrodes behave as two interface devices, membrane/electrolyte interface and membrane/metal interface. 18) Coated wire electrodes (CWEs) for some antispasmodic drugs, 19) quaternary ammonium cleaning agents, 20) some cations (silver, 21) palladium 22) ) and some anions 23) (chloride, bromide, iodide, thiocyanate) have been described. Also coated graphite rods have been used as sensors for the determination of some drugs such as atenolol, 24) tizanidine 25) and thiopental.…”

Section: Resultsmentioning

confidence: 99%

Miniaturized Membrane Sensors for the Determination of Rivastigmine Hydrogen Tartrate

El-Kosasy

Salem

El-Bardicy

et al. 2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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Section: Resultsmentioning

confidence: 99%

Miniaturized Membrane Sensors for the Determination of Rivastigmine Hydrogen Tartrate

El-Kosasy

Salem

El-Bardicy

et al. 2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Ion selective electrodes have been proven as an inexpensive and simple analytical technique with remarkable detection sensitivity, minimal sample pretreatment and ease of miniaturization rather than other analytical. Coated wire ion selective electrodes [9,10], in which the membrane is casted onto a solid-like graphite, Ag, Cu, Pt, etc., can also be used as long as the matrix of the membrane does not react with the internal wire. The advantage of using coated wire is that they can be used in small volume of sample, simple design (absence of internal solution), mechanical flexibility, and the possibility of miniaturization and microfabrication.…”

Section: Dap (Dapoxetine Hcl) Is Designated Chemically As (S)-nmentioning

confidence: 99%

Electrochemical Determination of Dapoxetine HCl in Biological Fluids Using Coated Wire Electrod

Alturiqi¹

2016

JCCE

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Coated wire sensor for potentiometric determination of DAP (dapoxetine HCl) in pure form and in biological fluids based on DAP-TPB (dapoxetine-tetraphenyl borate) as the sensing element in the presence of DOP (dioctylphthalate) as the plasticizing solvent mediator was prepared. The best performance was obtained with a membrane composition of 10.0% (w/w) ion-pair, 45.0% DOP (w/w) and 45.0% PVC (w/w). The electrode showed a Nernstian response (with a slope of 58.70 mV decade -1 ) for the concentration range of 4.2 × 10 −5 -1.0 × 10 −2 mol/L. It illustrates a relatively fast response time in the whole concentration range (~15 s) in a pH range of 3.0-7.5 . The selectivity coefficients were determined in relation to several inorganic and organic species. DAP is determined successfully in pure solutions and in biological fluids using the standard additions and potentiometric titrations methods.

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“…It is well known that the performance characteristics of a given CMCPE based on ion-exchangers depend to a large extent on the nature of these ion-exchangers and their lipophilicities [36], the type of solvent mediator [37] and any additives used [38]. Thus, the influences of paste composition, nature and amount of solvent mediator, and amount of additives, such as oleic acid or sodium tetraphenylborate, on the potential response of the proposed sensor were tested and the obtained results are given in Table 1.…”

Section: Composition Of the Electrodementioning

confidence: 99%

Potentiometric Response of Modified Carbon Paste Electrode Based on Mixed Ion‐Exchangers

Shawish

2008

Electroanalysis

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A new chemically modified carbon paste electrode based on a mixture of two ion-exchangers namely chlorpheniramine-silicotungstate (CPM-ST) and chlorpheniramine-tetraphenylborate (CPM-TPB) as ion-exchange site for determination of chlorpheniramine maleate (CPM) was described. The best performance was exhibited by the electrode having the paste containing 3.0 wt% ion-exchangers (CPM-ST&CPM-TPB), 48.5 wt% graphite, 47.5 wt% DOPh and 1.0 wt% NaTPB. The proposed chemically modified carbon paste electrode exhibited a Nernstian response for CPM over a wide concentration range of 1.2 Â 10 À6 to 1.0 Â 10 À2 M with a detection limit of 5.1 Â 10 À7 M between pH 4.5 and 7.7 with fast response 10 s. The sensor showed good selectivity for CPM with respect to a large number of inorganic cations, organic cations, sugars, amino acids and some common drug excipients. The modified electrode was applied to potentiometric determination of CPM in its pharmaceutical preparations and biological fluids (serum and urine) with average recoveries of 97.5 -102% and relative standard deviations of 0.32 -1.97%.

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Improving the detection limits of antispasmodic drugs electrodes by using modified membrane sensors with inner solid contact

Cited by 44 publications

References 26 publications

Miniaturized Membrane Sensors for the Determination of Rivastigmine Hydrogen Tartrate

Miniaturized Membrane Sensors for the Determination of Rivastigmine Hydrogen Tartrate

Electrochemical Determination of Dapoxetine HCl in Biological Fluids Using Coated Wire Electrod

Potentiometric Response of Modified Carbon Paste Electrode Based on Mixed Ion‐Exchangers

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