The process of creating an accident-resistant fuel system (AFS) of a helicopter using mathematical modeling is considered. Possibility of applying optimization algorithms in mathematical modeling of parameters of units of accident-resistant fuel system of helicopter in domestic software complex SimInTech is studied. An approach to solving the problem of optimizing given parameters, both in theory and in practice, is described. Results of the simplest optimization of AFS parameters for nominal operation mode are covered, examples of algorithms for selection of unit parameters are shown. This method of researching the system will allow, with a high degree of accuracy, to determine the necessary parameters at the design stage of the system. It is worth noting that the functionality of the developed dynamic mathematical model in the SimInTech software package is sufficient to perform tasks not only of the conceptual design stage, but also of the subsequent stages of the AFS life cycle.