2020
DOI: 10.1038/s41598-020-63646-9
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Impulsivity is a heritable trait in rodents and associated with a novel quantitative trait locus on chromosome 1

Abstract: Differential gene expression within the identified linkage region in highly-impulsive rats. To identify potential candidate genes within the linkage region we conducted a microarray analysis to investigate differences in transcript levels between HI and LI from both the outbred base population and animals from the sixth generation of the pedigree to identify common alterations in transcriptome expression associated with impulsivity. We investigated transcript expression in the NAcC, NAcS and in the case of six… Show more

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Cited by 8 publications
(6 citation statements)
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References 84 publications
(97 reference statements)
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“…This supports previous findings in both human and animal literature that impulsivity is a heritable trait. Heritability estimates for premature responding reported here are greater than past estimates derived from measures of response to selection in outbred rats 76 . Delay discounting heritability estimates are on par with estimates that have been reported previously for inbred mice populations, 42,77 while estimates for behavioral flexibility in reversal learning are lower than what has been reported in inbred BXD mice 36 .…”
Section: Discussioncontrasting
confidence: 74%
“…This supports previous findings in both human and animal literature that impulsivity is a heritable trait. Heritability estimates for premature responding reported here are greater than past estimates derived from measures of response to selection in outbred rats 76 . Delay discounting heritability estimates are on par with estimates that have been reported previously for inbred mice populations, 42,77 while estimates for behavioral flexibility in reversal learning are lower than what has been reported in inbred BXD mice 36 .…”
Section: Discussioncontrasting
confidence: 74%
“…This supports previous findings in both human and animal literature that impulsivity is a heritable trait. Heritability estimates for premature responding reported here are greater than past estimates derived from measures of response to selection in outbred rats (Jupp et al, 2020).…”
Section: Impulsivitycontrasting
confidence: 74%
“…For instance, impulsivity has been reported as sex dependent in both humans ( Cross et al, 2011 ; Weafer and de Wit, 2014 ) and rodents ( Weafer and de Wit, 2014 ; Soares et al, 2018 ), but the direction and strength of such effect depend on the assessed dimension. Additional variability may arise due to the mediation of other factors, as hormonal cycle in women ( Diekhof, 2015 ) and female rats ( Swalve et al, 2016 ), age ( Soares et al, 2018 , rats; Rosenbaum and Hartley, 2019 , humans), genetics ( Bezdjian et al, 2011 , humans; Soares et al, 2018 , rats; Jupp et al, 2020 , rats), or environment ( Bezdjian et al, 2011 , humans; Kirkpatrick et al, 2013 , rats). These influences, as well as their human–rodent parallels, are of high importance for the development of translational research.…”
Section: Discussionmentioning
confidence: 99%