In focus in HCB

Taatjes, Douglas J.; Roth, Jürgen

doi:10.1007/s00418-019-01831-2

Cited by 3 publications

(3 citation statements)

References 38 publications

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“…As we began with the Editorial in December 2019 for the publications in Histochemistry and Cell Biology in 2017 (Taatjes and Roth 2019), here we look at the download number of manuscripts published in 2019 in the journal to ascertain their appreciation by our readership during the following 2 years. Noteworthily, 21% of the published papers fell into the category ≥ 1000 times downloaded (Table 1), and 34% were downloaded between 500 and 999 times.…”

Section: Most Popular Articles Published In Hcb In 2019mentioning

confidence: 99%

In focus in HCB

Taatjes

Roth

2022

Histochem Cell Biol

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The Editorial of the first issue of Histochemistry and Cell Biology in 2022 starts with "Most popular articles published in HCB in 2019" and continues to highlight one Review about dynamic changes of histone methylation in mammalian oocytes and early embryos and three Original Articles reporting (1) that fat causes necrosis and inflammation in human steatotic liver, (2) the effect of a P2X7 receptor antagonist in a rat model of ulcerative colitis, and (3) NANOS3 downregulation in Down syndrome hiPSCs. We wish you good reading!

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Section: Most Popular Articles Published In Hcb In 2019mentioning

confidence: 99%

In focus in HCB

Taatjes

Roth

2022

Histochem Cell Biol

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“…The number of pdf downloads is one among other criteria to assess the overall impact of a scientific publication. As we began with the Editorial in December 2019 (Taatjes and Roth 2019) for the publications in HCB in 2017, here we look at the manuscripts published in 2018 in HCB to ascertain their appreciation by our readership during the following 2 years. Noteworthy, 29.35% of the published papers fell into the category ≥ 1000 times downloaded (Table 1), and 26.60% were downloaded between 500 and 999 times.…”

Section: Most Popular Articles Published In Hcb In 2018mentioning

confidence: 99%

In focus in HCB

Taatjes

Roth

2020

Histochem Cell Biol

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“…Prior investigations conducted in a laboratory have unveiled the presence of abundant preadipocytes within the superficial fascia, capable of differentiating into mature adipocytes and forming a thin adipose layer [ 6 – 8 ]. Mast cells, adipocytes, and newly formed primitive adipose lobules are spatially correlated with each other in superficial fascia [ 6 , 9 , 10 ]. Notably, investigations have identified mast cells, along with their degranulated component heparin, as the principal endogenous factors responsible for stimulating and facilitating fascial adipogenesis, both in vitro and in vivo [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Suramin, an antiparasitic drug, stimulates adipocyte differentiation and promotes adipogenesis

Li,

Dong,

Han

et al. 2023

Lipids Health Dis

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Background Previous studies demonstrated that mast cells with their degranulated component heparin are the major endogenous factors that stimulate preadipocyte differentiation and promote fascial adipogenesis, and this effect is related to the structure of heparin. Regarding the structural and physiological properties of the negatively charged polymers, hexasulfonated suramin, a centuries-old medicine that is still used for treating African trypanosomiasis and onchocerciasis, is assumed to be a heparin-related analog or heparinoid. This investigation aims to elucidate the influence of suramin on the adipogenesis. Methods To assess the influence exerted by suramin on adipogenic differentiation of primary white adipocytes in rats, this exploration was conducted both in vitro and in vivo. Moreover, it was attempted to explore the role played by the sulfonic acid groups present in suramin in mediating this adipogenic process. Results Suramin demonstrated a dose- and time-dependent propensity to stimulate the adipogenic differentiation of rat preadipocytes isolated from the superficial fascia tissue and from adult adipose tissue. This stimulation was concomitant with a notable upregulation in expression levels of pivotal adipogenic factors as the adipocyte differentiation process unfolded. Intraperitoneal injection of suramin into rats slightly increased adipogenesis in the superficial fascia and in the epididymal and inguinal fat depots. PPADS, NF023, and NF449 are suramin analogs respectively containing 2, 6, and 8 sulfonic acid groups, among which the last two moderately promoted lipid droplet formation and adipocyte differentiation. The number and position of sulfonate groups may be related to the adipogenic effect of suramin. Conclusions Suramin emerges as a noteworthy pharmaceutical agent with the unique capability to significantly induce adipocyte differentiation, thereby fostering adipogenesis.

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In focus in HCB

Cited by 3 publications

References 38 publications

In focus in HCB

In focus in HCB

In focus in HCB

Suramin, an antiparasitic drug, stimulates adipocyte differentiation and promotes adipogenesis

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