In-phantom characterisation studies at the Birmingham Accelerator-Generated epIthermal Neutron Source (BAGINS) BNCT facility

Culbertson, C. N.; Green, Stuart; Mason, Anna J; Picton, David M; Baugh, Gareth; Hugtenburg, Richard P.; Yin, Z.; Scott, Malcolm; Nelson, J. M.

doi:10.1016/j.apradiso.2004.05.057

Cited by 48 publications

(19 citation statements)

References 6 publications

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“…This is not surprising: FLUKA has been used in several studies and is validated by various experiments [33][34][35][36]. We matched the FLUKA data to experimental results obtained via fairly standard methodology of measurements of neutron fluxes using Mn activation foils as has been performed in multiple studies [23,21,22,43,42,41], and often around accelerators which have been used as a neutron source for therapy purposes [28,13,8,39,27]. We suggest that the match in this instance is remarkably good, given that we were using neutron production rates derived at another centre.…”

Section: Discussionmentioning

confidence: 93%

An investigation of the neutron flux in bone-fluorine phantoms comparing accelerator based in vivo neutron activation analysis and FLUKA simulation data

Mostafaei

McNeill

Chettle

et al. 2015

Nuclear Instruments and Methods in Physics Research Section B:

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Section: Discussionmentioning

confidence: 93%

An investigation of the neutron flux in bone-fluorine phantoms comparing accelerator based in vivo neutron activation analysis and FLUKA simulation data

Mostafaei

McNeill

Chettle

et al. 2015

Nuclear Instruments and Methods in Physics Research Section B:

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“…At present, research and development of acceleratorbased irradiation systems for BNCT are underway at several institutions [24][25][26][27]. In Japan, BNCT using various accelerator-based irradiation systems including C-BENS may be carried out at multiple facilities in the near fu- ture.…”

Section: Introductionmentioning

confidence: 99%

Advances in boron neutron capture therapy (BNCT) at kyoto university - From reactor-based BNCT to accelerator-based BNCT

Sakurai

Tanaka

Takata

et al. 2015

Journal of the Korean Physical Society

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At the Kyoto University Research Reactor Institute (KURRI), a clinical study of boron neutron capture therapy (BNCT) using a neutron irradiation facility installed at the research nuclear reactor has been regularly performed since February 1990. As of November 2014, 510 clinical irradiations were carried out using the reactor-based system. The world's first accelerator-based neutron irradiation system for BNCT clinical irradiation was completed at this institute in early 2009, and the clinical trial using this system was started in 2012. A shift of BCNT from special particle therapy to a general one is now in progress. To promote and support this shift, improvements to the irradiation system, as well as its preparation, and improvements in the physical engineering and the medical physics processes, such as dosimetry systems and quality assurance programs, must be considered.

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“…Monte-Carlo (MC) models of the source and detector systems provide a means to account in a precise way for energy absorbed in the detector, allowing for primary and secondary radiation processes in megavoltage radiotherapy [1] and for mixed radiation sources such as boron neutron capture therapy (BNCT) [2].…”

Section: Introductionmentioning

confidence: 99%

Modeling dose response to synchrotron X-rays in solid-state and biological systems

Hugtenburg

Saeedi

Bradley

2007

Radiation Effects and Defects in Solids

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The Monte-Carlo method is used to model perturbation to the dose response of solid-state detectors and biological systems in the vicinity of the K-edge of constituent elements. Diamond detectors are examined where silver-based (Ag) solders are used to form electrical contact with the diamond crystal. Perturbation from photoelectric interactions with Ag lead to a dose response that increases gradually above the K-edge of Ag (25.5 keV) reaching a maximum around 45 keV. Dose enhancements associated with synchrotron-based photon activation therapy (PAT) with platinum (Pt) are also examined. Perturbation from photoelectric interactions with Pt leads to a dose response that may increase to a maximum at the K-edge of Pt but falls dramatically above edge. For large volumes of irradiation, such as is typical for radiation therapy of the brain, self-absorption leads to a decrease in dose response above edge indicating that a high degree of localization of activating material is required for the treatment approach to be successful.

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In-phantom characterisation studies at the Birmingham Accelerator-Generated epIthermal Neutron Source (BAGINS) BNCT facility

Cited by 48 publications

References 6 publications

An investigation of the neutron flux in bone-fluorine phantoms comparing accelerator based in vivo neutron activation analysis and FLUKA simulation data

An investigation of the neutron flux in bone-fluorine phantoms comparing accelerator based in vivo neutron activation analysis and FLUKA simulation data

Advances in boron neutron capture therapy (BNCT) at kyoto university - From reactor-based BNCT to accelerator-based BNCT

Modeling dose response to synchrotron X-rays in solid-state and biological systems

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