In rats, the behavioral profile of CCK-8 related peptides resembles that of antipsychotic agents

Ree, Jan M. van; Gaffori, Odile; Wied, D. de

doi:10.1016/0014-2999(83)90031-6

Cited by 177 publications

(28 citation statements)

References 37 publications

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“…Consistent with previous reports, 1 to 10 g/kg of SC caerulein was able to prevent amphetamine-induced hyperlocomotion, and high doses decreased spontaneous motor activity (Crawley et al 1981;Van Ree et al 1983;Vasar et al 1991). This is consistent with a neuroleptic-like effect.…”

Section: Discussionsupporting

confidence: 92%

“…Systemic administration of CCK analogs in rats have been shown to modify behavior (Van Ree et al 1983;Nair et al 1986) and brain function (Kihara et al 1992(Kihara et al , 1993 in a manner consistent with a neuroleptic-like action. For example, systemically administered CCK agonists block amphetamine-induced hyperlocomotion (Crawley et al 1981;Van Ree et al 1983;Vasar et al 1991) and modulate central dopamine turnover (Kihara 1992(Kihara , 1993.…”

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confidence: 99%

“…For example, systemically administered CCK agonists block amphetamine-induced hyperlocomotion (Crawley et al 1981;Van Ree et al 1983;Vasar et al 1991) and modulate central dopamine turnover (Kihara 1992(Kihara , 1993. Based upon these findings, the effects of systemically administered CCK analogs in schizophrenia patients were examined in a series of clinical trials (reviewed in Nair et al 1986 andAlbus 1988).…”

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confidence: 99%

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Antipsychotic Potential of CCK-Based Treatments: An Assessment Using the Prepulse Inhibition Model of Psychosis

Feifel

Reza

Robeck

1999

Neuropsychopharmacology

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Section: Discussionsupporting

confidence: 92%

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Antipsychotic Potential of CCK-Based Treatments: An Assessment Using the Prepulse Inhibition Model of Psychosis

Feifel

Reza

Robeck

1999

Neuropsychopharmacology

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“…Microinjection of CCK into the nucleus accumbens of the rat has been shown to cause a potentiation of the effects of dopamine and apomorphine on two dopaminergically mediated behaviours, stereotypy and hyperlocomotion (Crawley, 1985); again this is to be expected if'CCK were increasing dopamine release. In contrast to these results however Van Ree et al (1983) (Hill and Woodruff, personal communication). We were unable to find any effect of CCK8S on basal or potassium-stimulated dopamine release from the striatum.…”

Section: Resultscontrasting

confidence: 49%

Characterization of cholecystokinin octapeptide‐stimulated endogenous dopamine release from rat nucleus accumbens in vitro

Marshall

Barnes

Pinnock

et al. 1990

British J Pharmacology

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1 The effect of cholecystokinin sulphated octapeptide (CCK8S) on endogenous dopamine release was examined in rat striatal and nucleus accumbens slices, by high performance liquid chromatography (h.p.l.c.) with electrochemical detection. 2 CCK8S was shown to increase dopamine release from slices of nucleus accumbens but not striatum in a dose-dependent manner between 0.1 and 1OpM.3 Pentagastrin was without effect on dopamine release at doses up to 10 M. 4 The dopamine release produced in the presence of CCK8S was abolished by preincubation of the slice with 1.0 or 1O.OnM L-364,718 (the CCKA-selective antagonist) while 1 pM L-365,260 (the CCKB-selective antagonist) had no action. 5 These results suggest that the CCK8S-evoked release of dopamine from the nucleus accumbens is mediated by a CCKA-receptor.

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“…CLN at the dose of 80 ,ug/kg suppressed powerfully both SKF 38393-induced behavior and the level of awakening. CLN has a neuroleptic like effect (11). A neuroleptic such as haloperidol acutely suppressed the behavior induced by a dopamine agonist, but there was a rebound increase (12).…”

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Delayed Supprressive Effect of a Low Dose of Caerulein on the Grooming Behavior Induced by the D1-Receptor Agonist SKF 38393.

Masuda¹,

Murai²,

Saito³

et al. 1992

Jpn.J.Pharmacol

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ABSTRACT-Caerulein (CLN, 0.8-80,ug/kg, s.c.) was administered to male rats 10 min or 24 hr be fore the injection of SKF 38393 (3 mg/kg, i.p.). The increased mouth movement and grooming be havior by SKF 38393 were suppressed dose-dependently by CLN 10 min before the SKF 38393. CLN at the dose of 0.8 ,ug/kg, given 24 hr before the SKF 38393, suppressed the grooming behavior by SKF 38393. These findings suggest that a low dose of CLN, but not a high dose, had a delayed suppressive effect on the grooming behavior induced by an excess of D,-activity.Keywords: Caerulein, SKF 38393, Grooming behaviorLong-term administration of a neuroleptic to schizo phrenic patients can often result in involuntary dys kinetic disorders such as tardive dyskinesia, which is thought to be mediated by an increased dopaminergic activity in the striatum. Chronic treatment of rats with neuroleptics cause an increase in mouth movements. The increased mouth movements are used as an animal model of tardive dyskinesia (1, 2). The increase in mouth movements is also induced by a single adminis tration of the selective dopamine Di-agonist SKF 38393 (3, 4). The increased mouth movements of the rat in duced by the long-term administration of neuroleptics and that induced by the administration of the selective D,-agonist SKF 38393 resemble each other in the aspect that both are characterized by a relative excess of D, activity (3, 4). Cholecystokinin octapeptide (CCK-8) suppresses both SKF 38393-induced behavior and chron ic neuroleptic-induced involuntary dyskinetic disorders (2, 5). This suggests that CCK-8 may be of use against involuntary dyskinetic disorders. These studies were carried out with an emphasis on analyzing the immedi ate effect of CCK-8. Caerulein (CLN), an analogue of CCK-8, has a long lasting effect on the monoamine level in rat brain re gions (6). Behavioral studies showed the long-lasting effect of CLN (7,8). For example, Ogawa et al. (8) re ported long-lasting effect of CLN on permanent motor behavioral abnormalities induced by the neurotoxin iminodipropionitrile. Moreover, CLN produced biphasic and long-lasting improvement in a schizophrenic patient with bucco-lingual dyskinesia (9). These reports suggest that CLN has a continuous or delayed suppressive effect on involuntary movements. In this study, we de termined if CLN has a delayed suppressive effect on the mouth movements and grooming behavior induced by SKF 38393.Eighty male Sprague-Dawley rats (Nihon SLC, Shizu oka, Japan), initially weighing 250-300g, were housed three per cage on a 12-hr light -12-hr dark cycle and allowed standard food pellets and water ad libitum for one week before the experiment.To test the immediate effect of CLN, five rats were placed individually in transparent boxes (18 X 26 X 28 cm) and left there for one hour to acclimate them. Then CLN (ceruletide diethylamine, synthesized at the Shionogi Research Pharmaceuticals Laboratories) was subcutaneously administered in doses of 0.8, 8 and 80 ,ug/kg to the 1st, 2nd, and 3rd rat, respectively, and sa...

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In rats, the behavioral profile of CCK-8 related peptides resembles that of antipsychotic agents

Cited by 177 publications

References 37 publications

Antipsychotic Potential of CCK-Based Treatments: An Assessment Using the Prepulse Inhibition Model of Psychosis

Antipsychotic Potential of CCK-Based Treatments: An Assessment Using the Prepulse Inhibition Model of Psychosis

Characterization of cholecystokinin octapeptide‐stimulated endogenous dopamine release from rat nucleus accumbens in vitro

Delayed Supprressive Effect of a Low Dose of Caerulein on the Grooming Behavior Induced by the D1-Receptor Agonist SKF 38393.

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