2014
DOI: 10.1007/s10441-014-9226-8
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In Silico Analysis of Acinetobacter baumannii Phospholipase D as a Subunit Vaccine Candidate

Abstract: The rate of human health care-associated infections caused by Acinetobacter baumannii has increased significantly in recent years for its remarkable resistance to desiccation and most antibiotics. Phospholipases, capable of destroying a phospholipid substrate, are heterologous group of enzymes which are believed to be the bacterial virulence determinants. There is a need for in silico studies to identify potential vaccine candidates. A. baumannii phospholipase D (PLD) role has been proved in increasing organis… Show more

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Cited by 25 publications
(14 citation statements)
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“…However, issues regarding safety, acceptability and ability to provide comprehensive protection against different strains of A. baumannii may limit the development of these as vaccine products (8). Recognizing the potential of surface protein antigens as potential vaccine antigens, in silico methods that are largely based on the first step of the reverse vaccinology approach (9,10) have been used to identify potential vaccine candidates (8,11). However, the in silico approaches for reverse vaccinology, such as using the presence of a signal peptide to select for potential surface proteins, cannot predict surface accessibility.…”
Section: Introductionmentioning
confidence: 99%
“…However, issues regarding safety, acceptability and ability to provide comprehensive protection against different strains of A. baumannii may limit the development of these as vaccine products (8). Recognizing the potential of surface protein antigens as potential vaccine antigens, in silico methods that are largely based on the first step of the reverse vaccinology approach (9,10) have been used to identify potential vaccine candidates (8,11). However, the in silico approaches for reverse vaccinology, such as using the presence of a signal peptide to select for potential surface proteins, cannot predict surface accessibility.…”
Section: Introductionmentioning
confidence: 99%
“…The whole proteome of C. jejuni has been investigated for antigenicity, allergenicity, MHC binding, conservancy, and population coverage [58] and several conserved T-cell epitopes have been selected covering more than 80% of the human population. [65].…”
Section: Prediction Of Bacterial Immunogensmentioning
confidence: 99%
“…The analysis revealed 897 protein sequences. Applying immunoinformatics (including VaxiJen) their number was reduced to 65. Nine were tested for immunogenicity using a murine gastrointestinal infection model.…”
mentioning
confidence: 99%
“…Nowadays, bioinformatics is reliably employed in biology researches. It could be harnessed in vaccine design as well as epitope mapping purposes (Jahangiri et al 2011 F. Sefid et al Rahbar et al 2012;Hosseingholi et al 2014). In the present study we exploit bioinformatic tools to introduce the best regions of BauA as antigenic determinants in order to design (a) novel construct (s) as vaccine or diagnostics.…”
Section: Introductionmentioning
confidence: 97%