In silico comparative structural and functional analysis of dengue virus (Serotypes 1 to 4) envelope protein
Earl Adriane Cano,
Alphonsus Maligaya,
Barbara Elle Manuales
et al.
Abstract:Dengue virus is classified into serotypes, DENV-1, DENV-2, DENV-3, and DENV-4, causing symptoms from mild fevers to severe complications. This study comparatively analyzes the structural and functional variations of envelope (E) protein across DENV serotypes through computational methods. Multiple sequence alignment, physicochemical characterization, and secondary and tertiary structural comparison are conducted using ClustalW, ProtParam, and SWISS-MODEL. DENV-1 and DENV-3 E proteins show the highest identity,… Show more
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