In Silico Methods for the Discovery of Kv7.2/7.3 Channels Modulators: A Comprehensive Review
Claudio Stagno,
Francesca Mancuso,
Tania Ciaglia
et al.
Abstract:The growing interest in Kv7.2/7.3 agonists originates from the involvement of these channels in several brain hyperexcitability disorders. In particular, Kv7.2/7.3 mutants have been clearly associated with epileptic encephalopathies (DEE) as well as with a spectrum of focal epilepsy disorders, often associated with developmental plateauing or regression. Nevertheless, there is a lack of available therapeutic options, considering that retigabine, the only molecule used in clinic as broad-spectrum Kv7 agonist, h… Show more
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