2023
DOI: 10.3389/fchem.2023.1316779
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In silico studies on cytotoxicity and antitumoral activity of acetogenins from Annona muricata L

Houéfa Egidia Fallon Adido,
Cristian Kallahan Silva Chagas,
Gleison Gonçalves Ferreira
et al.

Abstract: As life expectancy increases, the number of people affected by cancer is increasing. The available drugs still cause several adverse reactions, and it is important to look for less toxic drugs that act on resistant cancers. The present study evaluated the antitumor potential of acetogenins. Through a literature review, 44 acetogenins isolated from Annona muricata were selected and subjected to in silico studies to predict the physicochemical properties, pharmacokinetics (Preadmet and Admet lab), toxicity (Prea… Show more

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