In Situ Detection and Identification of Trace Explosives by Raman Microscopy

Cheng, C.; Kirkbride, Tracy; Batchelder, D. N.; Lacey, R. W.; Sheldon, T. G.

doi:10.1520/jfs13756j

Cited by 92 publications

(48 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Raman spectrometry measures the energy change resulting from the excitation laser inelastically interacting with different modes of molecular vibrations (Raman scattering). The resulting spectrum is commonly used as a fingerprint to identify molecules (Cheng et al, 1995). Using qualitative spectrometry (such as Raman), rather than chemical analysis, makes the identification of melanins in biological systems easier.…”

Section: Introductionmentioning

confidence: 99%

Spiders have melanin after all

Hsiung

Blackledge

Shawkey

2015

Journal of Experimental Biology

View full text Add to dashboard Cite

Melanin pigments are broadly distributed in nature -from bacteria to fungi to plants and animals. However, many previous attempts to identify melanins in spiders were unsuccessful, suggesting that these otherwise ubiquitous pigments were lost during spider evolution. Yet, spiders exhibit many dark colours similar to those produced by melanins in other organisms, and the low solubility of melanins makes isolation and characterization difficult. Therefore, whether melanins are truly absent or have simply not yet been detected is an open question. Raman spectroscopy provides a reliable way to detect melanins in situ, without the need for isolation. In this study, we document the presence of eumelanin in diverse species of spiders using confocal Raman microspectroscopy. Comparisons of spectra with theoretically calculated data falsify the previous hypothesis that dark colours are produced solely by ommochromes in spiders. Our data indicate that melanins are present in spiders and further supporting that they are present in most living organisms.

show abstract

Section: Introductionmentioning

confidence: 99%

Spiders have melanin after all

Hsiung

Blackledge

Shawkey

2015

Journal of Experimental Biology

View full text Add to dashboard Cite

show abstract

“…Specific applications of Raman spectroscopy to forensic science have been reviewed by Kuptsov (12), and several groups have employed Raman microscopy or fiber optic probes for the analysis and identification of explosive materials (13,14,15,16,17,18). The identification of illegal drugs when dispersed through solid mixtures has been investigated by various groups who have demonstrated the possibility of using near-IR FT-Raman or UVresonance Raman spectroscopy for narcotic identification (5,19).…”

mentioning

confidence: 99%

Identifications and Quantitative Measurements of Narcotics in Solid Mixtures Using Near-IR Raman Spectroscopy and Multivariate Analysis

Ryder

O’Connor

Glynn

1999

Journal of Forensic Sciences

View full text Add to dashboard Cite

Raman spectroscopy offers the potential for the identification of illegal narcotics in seconds by inelastic scattering of light from molecular vibrations. In this study cocaine, heroin, and MDMA were analyzed using near-IR (785 nm excitation) micro-Raman spectroscopy. Narcotics were dispersed in solid dilutants of different concentrations by weight. The dilutants investigated were foodstuffs (flour, baby milk formula), sugars (glucose, lactose, maltose, mannitol), and inorganic materials (Talc powder, NaHCO3, MgSO4·7H2O). In most cases it was possible to detect the presence of drugs at levels down to ∼10% by weight. The detection sensitivity of the Raman technique was found to be dependent on a number of factors such as the scattering cross-sections of drug and dilutant, fluorescence of matrix or drug, complexity of dilutant Raman spectrum, and spectrometer resolution. Raman spectra from a series of 20 mixtures of cocaine and glucose (0–100% by weight cocaine) were collected and analyzed using multivariate analysis methods. An accurate prediction model was generated using a Partial Least Squares (PLS) algorithm that can predict the concentration of cocaine in solid glucose from a single Raman spectrum with a root mean standard error of prediction of 2.3%.

show abstract

“…Gupta used fast-time resolved Raman spectroscopy to study the flow of vibrational energy behind a shock wave in nitromethane (40). Also around this time, the use of the Renishaw Raman microscope for explosive detection and analysis was first reported (41). Limits of detection for most explosives studied were in the picogram range.…”

Section: Laser Raman Spectroscopymentioning

confidence: 99%

Laser-Based Detection Methods for Explosives

Munson¹,

Gottfried²,

Lucia³

et al. 2007

View full text Add to dashboard Cite

Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing the burden, to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number.

show abstract

In Situ Detection and Identification of Trace Explosives by Raman Microscopy

Cited by 92 publications

References 10 publications

Spiders have melanin after all

Spiders have melanin after all

Identifications and Quantitative Measurements of Narcotics in Solid Mixtures Using Near-IR Raman Spectroscopy and Multivariate Analysis

Laser-Based Detection Methods for Explosives

Contact Info

Product

Resources

About