In Situ Hybridization Utilizing a Y Chromosome Dna Probe

Eckert, Jordan W.; Buerkle, Carla J.; Major, Angela; Finegold, Milton J.; Brandt, Mary L.

doi:10.1097/00007890-199501150-00019

Cited by 8 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…But these strategies are very complicated and low efficient. Discordant gender transplants offer the benefit of having 100% of the cells marked, as opposed to retroviral transduction, where at best only 5-10% of the cells are marked [11] . In our experience, Y chromosome, uniquely existed in male cell, was initially acted as a marker with which male and female tissues were differentiated.…”

Section: Discussionmentioning

confidence: 99%

Disseminated tumor cells homing into rats’ liver: A new possible mechanism of HCC recurrence

Li¹,

Yang²,

Yang³

et al. 2004

WJG

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Disseminated tumor cells homing into rats’ liver: A new possible mechanism of HCC recurrence

Li¹,

Yang²,

Yang³

et al. 2004

WJG

View full text Add to dashboard Cite

show abstract

The fate of donor osteocytes in fine particulate bone powders during repair of bone defects in experimental rats

et al. 2012

View full text Add to dashboard Cite

Liver Repopulation and Correction of Metabolic Liver Disease by Transplanted Adult Mouse Pancreatic Cells

Wang

Al‐Dhalimy

Lagasse

et al. 2001

The American Journal of Pathology

112

View full text Add to dashboard Cite

The emergence of cells with hepatocellular properties in the adult pancreas has been described in several experimental models. To determine whether adult pancreas contains cells that can give rise to therapeutically useful and biochemically normal hepatocytes, we transplanted suspensions of wild-type mouse pancreatic cells into syngeneic recipients deficient in fumarylacetoacetate hydrolase and manifesting tyrosinemia. Four of 34 (12%) mutant mice analyzed were fully rescued by donor-derived cells and had normal liver function. Ten additional mice (29%) showed histological evidence of donor-derived hepatocytes in the liver. Previous work has suggested that pancreatic liver precursors reside within or close to pancreatic ducts. We therefore performed additional transplantations using either primary cell suspensions enriched for ducts or cultured ducts. Forty-four mutant mice were transplanted with cells enriched for pancreatic duct cells, but only three of the 34 (9%) recipients analyzed displayed donor-derived hepatocytes. In addition, 28 of the fumarylacetoacetate hydrolase-deficient mice were transplanted with cultured pancreatic duct cells, but no donor-derived hepatocytes were observed. Our results demonstrate for the first time that adult mouse pancreas contains hepatocyte progenitor cells capable of significant therapeutic liver reconstitution. However, contrary to previous reports, we were unable to detect these cells within the duct compartment.

show abstract

In Situ Hybridization Utilizing a Y Chromosome Dna Probe

Cited by 8 publications

References 0 publications

Disseminated tumor cells homing into rats’ liver: A new possible mechanism of HCC recurrence

Disseminated tumor cells homing into rats’ liver: A new possible mechanism of HCC recurrence

The fate of donor osteocytes in fine particulate bone powders during repair of bone defects in experimental rats

Liver Repopulation and Correction of Metabolic Liver Disease by Transplanted Adult Mouse Pancreatic Cells

Contact Info

Product

Resources

About