In Situ implantable, post-trauma microenvironment-responsive, ROS Depletion Hydrogels for the treatment of Traumatic brain injury

Qian, Feng; Han, Yuhan; Han, Zhengzhong; Zhang, Deyun; Zhang, Long; Zhao, Gang; Li, Shanshan; Jia, Guanghong; Yu, Rutong; Liu, Hongmei

doi:10.1016/j.biomaterials.2021.120675

Cited by 91 publications

(69 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, Qian et al. prepared an injectable hydrogel loaded with curcumin for ROS scavenging in traumatic brain injury to ameliorate the regeneration and recovery of neurons [ 85 ]. Fernandes et al.…”

Section: Ros-scavenging Nanomaterials That Promote Oxidative Damage Repair and Mechanisms Governing This Repairmentioning

confidence: 99%

Reactive-oxygen-species-scavenging nanomaterials for resolving inflammation

Huang

Zheng

et al. 2021

Materials Today Bio

View full text Add to dashboard Cite

Reactive oxygen species (ROS) mediate multiple physiological functions; however, the over-accumulation of ROS causes premature aging and/or death and is associated with various inflammatory conditions. Nevertheless, there are limited clinical treatment options that are currently available. The good news is that owing to the considerable advances in nanoscience, multiple types of nanomaterials with unique ROS-scavenging abilities that influence the temporospatial dynamic behaviors of ROS in biological systems have been developed. This has led to the emergence of next-generation nanomaterial-controlled strategies aimed at ameliorating ROS-related inflammatory conditions. Accordingly, herein we reviewed recent progress in research on nanotherapy based on ROS scavenging. The underlying mechanisms of the employed nanomaterials are emphasized. Furthermore, important issues in developing cross-disciplinary nanomedicine-based strategies for ROS-based inflammatory conditions are discussed. Our review of this increasing interdisciplinary field will benefit ongoing studies and clinical applications of nanomedicine based on ROS scavenging.

show abstract

Section: Ros-scavenging Nanomaterials That Promote Oxidative Damage Repair and Mechanisms Governing This Repairmentioning

confidence: 99%

Reactive-oxygen-species-scavenging nanomaterials for resolving inflammation

Huang

Zheng

et al. 2021

Materials Today Bio

View full text Add to dashboard Cite

show abstract

“…(D) Without hydrogel treatment, neuronal death and severe neuroinflammation were observed, and the secondary injury was aggravated. Reproduced from Qian et al (2021) with permission from the Elsevier.…”

Section: Nanozyme-based Treatment Of Inflammationmentioning

confidence: 99%

“…Given that most nanoparticles have difficulties in passing the BBB, non-invasive treatment is a desirable alternative therapy for brain diseases. Qian et al (2021) developed an in situ implantable, ROS-scavenging, and post-trauma responsive hydrogels for the treatment of TBI ( Figure 4A ). After injecting into the surgical cavity after TBI, the poly (propylene sulfide) 120 component of the hydrogels switched from a hydrophobic polymer to a hydrophilic one in the ROS-rich environment, and the triglycerol monostearate (TM) was cleaved by matrix metalloproteinases (MMP), releasing the embedded curcumin to reduce the ROS levels ( Figure 4B ).…”

Section: Treatment For Brain Diseases Based On Nanozymesmentioning

confidence: 99%

Nanozymes Regulate Redox Homeostasis in ROS-Related Inflammation

Liu

Dai

et al. 2021

Front. Chem.

View full text Add to dashboard Cite

Reactive oxygen species (ROS), in moderate amounts, play an essential role in regulating different physiological functions in organisms. However, increased amounts of ROS may cause oxidative stress and damage to biomolecules, leading to a variety of diseases including inflammation and even cancer. Therefore, ROS scavenging reagents are needed to maintain healthy levels of ROS. With considerable advances in nanotechnology, nanozymes possess SOD or CAT-like activities with outstanding free radical scavenging activity, facile synthesis conditions, and excellent biocompatibility. Based on these extraordinary properties, nanozymes has been used to modulate the redox homeostasis and relieve the ROS-related injury. This has led to the emergence of nanozyme-based therapies. In the current review, we presented recently developed applications of nanozymes to treat ROS-dependent disorders with an emphasis on inflammatory and brain diseases.

show abstract

“…Moreover, the hydrogels prepared by some synthetic polymers also have excellent properties. For example, Qian et al synthesized poly (propylene sulfide) 120 (PPS120), which has hydrophobicity- and reactive oxygen species (ROS)-quenching and H 2 O 2 -responsive abilities [ 72 ]. Reactive oxygen species depletion hydrogels were prepared by embedding PPS120 with Matrix metalloproteinase (MMP)-responsive triglycerol monostearate.…”

Section: General Materials For Mmp-cleavable Peptides-based Hydrogelsmentioning

confidence: 99%

Bone Regeneration Using MMP-Cleavable Peptides-Based Hydrogels

Chen

Zhou

Chen

et al. 2021

Gels

View full text Add to dashboard Cite

Accumulating evidence has suggested the significant potential of chemically modified hydrogels in bone regeneration. Despite the progress of bioactive hydrogels with different materials, structures and loading cargoes, the desires from clinical applications have not been fully validated. Multiple biological behaviors are orchestrated precisely during the bone regeneration process, including bone marrow mesenchymal stem cells (BMSCs) recruitment, osteogenic differentiation, matrix calcification and well-organized remodeling. Since matrix metalloproteinases play critical roles in such bone metabolism processes as BMSC commitment, osteoblast survival, osteoclast activation matrix calcification and microstructure remodeling, matrix metalloproteinase (MMP) cleavable peptides-based hydrogels could respond to various MMP levels and, thus, accelerate bone regeneration. In this review, we focused on the MMP-cleavable peptides, polymers, functional modification and crosslinked reactions. Applications, perspectives and limitations of MMP-cleavable peptides-based hydrogels for bone regeneration were then discussed.

show abstract

In Situ implantable, post-trauma microenvironment-responsive, ROS Depletion Hydrogels for the treatment of Traumatic brain injury

Cited by 91 publications

References 60 publications

Reactive-oxygen-species-scavenging nanomaterials for resolving inflammation

Reactive-oxygen-species-scavenging nanomaterials for resolving inflammation

Nanozymes Regulate Redox Homeostasis in ROS-Related Inflammation

Bone Regeneration Using MMP-Cleavable Peptides-Based Hydrogels

Contact Info

Product

Resources

About