In Situ Microfluidic Preparation and Solidification of Alginate Microgels

Damiati, Samar

doi:10.1007/s13233-020-8142-9

Cited by 24 publications

(13 citation statements)

References 42 publications

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“…The high content of G enhances the rigidity of the polymeric structure and thus results in improved results in tension and compression tests. [ 144 ]…”

Section: Alginatesmentioning

confidence: 99%

“…The increase in publications on alginates for biomimetic applications and the promising trends of an even greater increase in the coming years is mostly due to their tunable crosslinking properties, which may be exploited in several applications including tissue engineering, 3D‐bioprinting, as well as to mimic the native extracellular matrix, which provides a microenvironment that is capable to offer cell‐protective effect, to keep cellular functions and to enhance tissue formation. [ 144 ]…”

Section: Alginatesmentioning

confidence: 99%

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Biomimetic Biomaterials Based on Polysaccharides: Recent Progress and Future Perspectives

Silva

Carvalho

Moraes

et al. 2022

Macro Chemistry & Physics

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Nature is a source of diverse materials, including polysaccharides, which have been used to improve the quality of life. Besides being abundant and renewable, polysaccharides possess many advantages, such as biodegradability and biocompatibility, which allow them to be applied in different fields. They can be used in the design and development of renewable materials, thus contributing to a more sustainable society. Because of their advantages and versatility, polysaccharides may be incorporated in many systems, particularly biomimetic ones, to create outstanding sustainable solutions to problems that still need to be solved. Hence, nature not only offers resources but an inspiration to overcome issues. In this sense, this work aims to present an overview of current relevant biomimetic systems based on polysaccharides. Chitosan, cellulose, xanthan gum, alginates, pullulan, hyaluronic acid, schizophyllan, and oligomeric cyclodextrins are covered. The application of these polysaccharides in the design of biosensors, systems for environmental remediation, structural materials, drug delivery systems, tissue engineering among others is described. Finally, the challenges that still need to be faced and opportunities of application of these materials for the development of bioinspired technologies in the next future are highlighted.

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“…The high content of G enhances the rigidity of the polymeric structure and thus results in improved results in tension and compression tests. [ 144 ]…”

Section: Alginatesmentioning

confidence: 99%

Section: Alginatesmentioning

confidence: 99%

Biomimetic Biomaterials Based on Polysaccharides: Recent Progress and Future Perspectives

Silva

Carvalho

Moraes

et al. 2022

Macro Chemistry & Physics

View full text Add to dashboard Cite

show abstract

“…In the last two decades, microfluidic strategies for the production of natural polymer particles have become available, featuring the use of food-grade biopolymers and precise control over the morphology and size of biopolymer colloids, size ranging from 60 µm to 175 µm ( Figure 4 A) [ 42 , 43 , 44 ].…”

Section: Microfluidic Fabrication Of Food Dropletsmentioning

confidence: 99%

“…Oil encapsulation using alginate as encapsulating material can be carried out using technologies based on an external, internal, or inverse gelation mechanism, coupled with droplet microfluidics [ 44 ]. Recently, the production of alginate microgels containing multiple oil cores was reported using a two-step method involving a Pickering emulsion in a droplet microfluidic device.…”

Section: Microfluidic Fabrication Of Food Dropletsmentioning

confidence: 99%

Droplet Microfluidics for Food and Nutrition Applications

et al. 2021

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Droplet microfluidics revolutionizes the way experiments and analyses are conducted in many fields of science, based on decades of basic research. Applied sciences are also impacted, opening new perspectives on how we look at complex matter. In particular, food and nutritional sciences still have many research questions unsolved, and conventional laboratory methods are not always suitable to answer them. In this review, we present how microfluidics have been used in these fields to produce and investigate various droplet-based systems, namely simple and double emulsions, microgels, microparticles, and microcapsules with food-grade compositions. We show that droplet microfluidic devices enable unprecedented control over their production and properties, and can be integrated in lab-on-chip platforms for in situ and time-resolved analyses. This approach is illustrated for on-chip measurements of droplet interfacial properties, droplet–droplet coalescence, phase behavior of biopolymer mixtures, and reaction kinetics related to food digestion and nutrient absorption. As a perspective, we present promising developments in the adjacent fields of biochemistry and microbiology, as well as advanced microfluidics–analytical instrument coupling, all of which could be applied to solve research questions at the interface of food and nutritional sciences.

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“…This enables a considerable reduction of the ecological impact of research and development, and potentially increases the rate of production of new formulations. Drop microreactors have been successfully used for activities including the measurement of kinetic constants of chemical and biochemical reactions [2][3][4], drug-protein association constants [5], cell screening [6][7][8], synthesis of nanoparticles [9][10][11] and hydrogel particles [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Effect of Surfactant Dynamics on Flow Patterns Inside Drops Moving in Rectangular Microfluidic Channels

Kovalchuk

Simmons

2021

Colloids and Interfaces

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Drops contained in an immiscible liquid phase are attractive as microreactors, enabling sound statistical analysis of reactions performed on ensembles of samples in a microfluidic device. Many applications have specific requirements for the values of local shear stress inside the drops and, thus, knowledge of the flow field is required. This is complicated in commonly used rectangular channels by the flow of the continuous phase in the corners, which also affects the flow inside the drops. In addition, a number of chemical species are present inside the drops, of which some may be surface-active. This work presents a novel experimental study of the flow fields of drops moving in a rectangular microfluidic channel when a surfactant is added to the dispersed phase. Four surfactants with different surface activities are used. Flow fields are measured using Ghost Particle Velocimetry, carried out at different channel depths to account for the 3-D flow structure. It is shown that the effect of the surfactant depends on the characteristic adsorption time. For fast-equilibrating surfactants with a characteristic time scale of adsorption that is much smaller than the characteristic time of surface deformation, this effect is related only to the decrease in interfacial tension, and can be accounted for by the change in capillary number. For slowly equilibrating surfactants, Marangoni stresses accelerate the corner flow, which changes the flow patterns inside the drop considerably.

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In Situ Microfluidic Preparation and Solidification of Alginate Microgels

Cited by 24 publications

References 42 publications

Biomimetic Biomaterials Based on Polysaccharides: Recent Progress and Future Perspectives

Biomimetic Biomaterials Based on Polysaccharides: Recent Progress and Future Perspectives

Droplet Microfluidics for Food and Nutrition Applications

Effect of Surfactant Dynamics on Flow Patterns Inside Drops Moving in Rectangular Microfluidic Channels

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