In situ precision electrospinning as an effective delivery technique for cyanoacrylate medical glue with high efficiency and low toxicity

Dong, Ronglu; Qin, Chong-Chong; Qiu, Xue; Xu, Yan; Yu, Miao; Cui, Lin; Zhou, Yu; Zhang, H. D.; Jiang, Xingyu; Long, Yun-Ze

doi:10.1039/c5nr05786h

Cited by 52 publications

(23 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…cyanoacrylate-based adhesives) [16]. Cyanoacrylates and aldehyde-based adhesives have been largely associated with tissue inflammation, cell necrosis, and cytotoxicity [17,18]. Hydrogel-based adhesives and biologically derived fibrin glues have been shown to exhibit poor adhesion to wet tissues, and are not able to support tissue regeneration [19].…”

Section: Introductionmentioning

confidence: 99%

Engineering a sprayable and elastic hydrogel adhesive with antimicrobial properties for wound healing

et al. 2017

View full text Add to dashboard Cite

Hydrogel-based bioadhesives have emerged as alternatives for sutureless wound closure, since they can mimic the composition and physicochemical properties of the extracellular matrix. However, they are often associated with poor mechanical properties, low adhesion to native tissues, and lack of antimicrobial properties. Herein, a new sprayable, elastic, and biocompatible composite hydrogel, with broad-spectrum antimicrobial activity, for the treatment of chronic wounds is reported. The composite hydrogels were engineered using two ECM-derived biopolymers, gelatin methacryloyl (GelMA) and methacryloyl-substituted recombinant human tropoelastin (MeTro). MeTro/GelMA composite hydrogel adhesives were formed via visible light-induced crosslinking. Additionally, the antimicrobial peptide Tet213 was conjugated to the hydrogels, instilling antimicrobial activity against Gram (+) and (-) bacteria. The physical properties (e.g. porosity, degradability, swellability, mechanical, and adhesive properties) of the engineered hydrogel could be fine-tuned by varying the ratio of MeTro/GelMA and the final polymer concentration. The hydrogels supported in vitro mammalian cellular growth in both two-dimensional and three dimensional cultures. The subcutaneous implantation of the hydrogels in rats confirmed their biocompatibility and biodegradation in vivo. The engineered MeTro/GelMA-Tet213 hydrogels can be used for sutureless wound closure strategies to prevent infection and promote healing of chronic wounds.

show abstract

Section: Introductionmentioning

confidence: 99%

Engineering a sprayable and elastic hydrogel adhesive with antimicrobial properties for wound healing

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Adhesive sealant creating chemical interaction with the substrate by the diffusion of molecules to the tissue, has been described. Unfortunately, most of the available sealants have poor adhesion or biocompatibility [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Plasticised Regenerated Silk/Gold Nanorods Hybrids as Sealant and Bio-Piezoelectric Materials

et al. 2020

View full text Add to dashboard Cite

Manual and mechanical suturing are currently the gold standard for bowel anastomosis. If tissue approximation fails, anastomotic leaks occur. Anastomotic leaks may have catastrophic consequences. The development of a fully absorbable, biocompatible sealant material based on a bio-ink silk fibroin can reduce the chance of anastomotic leaks. We have produced a Ca-modified plasticised regenerated silk (RS) with gold nanorods sealant. This sealant was applied to anastomosed porcine intestine. Water absorption from wet tissue substrate applied compressive strains on hybrid RS films. This compression results in a sealant effect on anastomosis. The increased toughness of the hybrid plasticised RS resulted in the designing of a bio-film with superior elongation at break (i.e., ≈200%) and bursting pressure. We have also reported structure-dependent piezoelectricity of the RS film that shows a piezoelectric effect out of the plane. We hope that in the future, bowel anastomosis can be simplified by providing a multifunctional bio-film that makes feasible the mechanical tissue joint without the need for specific tools and could be used in piezoelectric sealant heads.

show abstract

“…The in situ electrospinning needs to precisely control the deposition range on a specified tumor tissue, which could avoid causing serious tissue adhesion especially in the abdominal cavity [ 14 ]. It has been reported by many researchers that the in situ precise electrospinning can be applied in the field of medicine [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Electric Field-Assisted In Situ Precise Deposition of Electrospun γ-Fe2O3/Polyurethane Nanofibers for Magnetic Hyperthermia

et al. 2018

View full text Add to dashboard Cite

A facial electrospinning method of in situ precise fabricating magnetic fibrous membrane composed of polyurethane (PU) nanofibers decorated with superparamagnetic γ-Fe2O3 nanoparticles with simultaneous heat generation in response to alternating magnetic field (AMF) is reported. In this method, a conical aluminum auxiliary electrode is used to regulate the electrostatic field and affect the process of electrospinning for the in situ rapid and precise deposition of electrospun γ-Fe2O3/PU fibers. The auxiliary conical electrode can extend the jet stabilization zone of the precursor solution four times longer than that of without auxiliary electrode, which can achieve the precise control of the fiber deposition area. Moreover, the electrospun composite fibrous membranes show a rapid temperature increase from room temperature to 43 °C in 70 s under the AMF, which exhibits faster heating rate and higher heating temperature compared to the samples fabricated without the assist of the auxiliary electrode. The present results demonstrate that the in situ precise electrospinning with the help of an auxiliary conical electrode has the potential as a manipulative method for preparing magnetic composite fibers as well as magnetic hyperthermia of cancer therapy.

show abstract

In situ precision electrospinning as an effective delivery technique for cyanoacrylate medical glue with high efficiency and low toxicity

Cited by 52 publications

References 38 publications

Engineering a sprayable and elastic hydrogel adhesive with antimicrobial properties for wound healing

Engineering a sprayable and elastic hydrogel adhesive with antimicrobial properties for wound healing

Plasticised Regenerated Silk/Gold Nanorods Hybrids as Sealant and Bio-Piezoelectric Materials

Electric Field-Assisted In Situ Precise Deposition of Electrospun γ-Fe2O3/Polyurethane Nanofibers for Magnetic Hyperthermia

Contact Info

Product

Resources

About