In situ reflection imaging and microspectroscopic study on three-dimensional crystal growth of L-phenylalanine under laser trapping

Chen, Jim Jui-Kai; Yuyama, Ken‐ichi; Sugiyama, Teruki; Masuhara, Hiroshi

doi:10.7567/1882-0786/ab4a9e

Cited by 5 publications

(6 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…LTIC has also been reported for undersaturated solutions of glycine in D 2 O and l -phenylalanine in H 2 O …”

Section: Discussionmentioning

confidence: 70%

“…LIPS droplets are highly concentrated with a higher refractive index compound, which may promote, and enhance, crystal growth Laser trapping-induced crystallization is demonstrated in various kinds of solutions of inorganic, small organic compounds and proteins, both in H 2 O and D 2 O super- and saturated solutions. Due to the long duration of laser irradiation (from a few seconds to hours), most researchers use heavy water to cope with the heating effects prominent in regular water. LTIC has also been reported for undersaturated solutions of glycine in D 2 O and l -phenylalanine in H 2 O Phase-separated liquid-like droplets have been observed in LTIC experiments prior to crystallization. , The reported size of these droplets can be larger than the laser spot size (a few microns to millimeters), and the lifetime varies based on experimental conditions. Critical experimental parameters for laser trapping-induced crystallization are the focal point of the laser, the laser power, the solvent used, and the solute concentration. Polymorph control was seen with LTIC by changing the polarization of the laser beam. Different morphologies are also induced in nonpolymorphic forming crystals by means of laser polarization …”

Section: Discussionmentioning

confidence: 89%

See 1 more Smart Citation

A Review of Laser-Induced Crystallization from Solution

Vikram

Nagaraj

Marques

et al. 2023

Crystal Growth & Design

View full text Add to dashboard Cite

Crystallization abounds in nature and industrial practice. A plethora of indispensable products ranging from agrochemicals and pharmaceuticals to battery materials are produced in crystalline form in industrial practice. Yet, our control over the crystallization process across scales, from molecular to macroscopic, is far from complete. This bottleneck not only hinders our ability to engineer the properties of crystalline products essential for maintaining our quality of life but also hampers progress toward a sustainable circular economy in resource recovery. In recent years, approaches leveraging light fields have emerged as promising alternatives to manipulate crystallization. In this review article, we classify laser-induced crystallization approaches where light-material interactions are utilized to influence crystallization phenomena according to proposed underlying mechanisms and experimental setups. We discuss nonphotochemical laser-induced nucleation, high-intensity laser-induced nucleation, laser trapping-induced crystallization, and indirect methods in detail. Throughout the review, we highlight connections among these separately evolving subfields to encourage the interdisciplinary exchange of ideas.

show abstract

“…LTIC has also been reported for undersaturated solutions of glycine in D 2 O and l -phenylalanine in H 2 O …”

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 89%

A Review of Laser-Induced Crystallization from Solution

Vikram

Nagaraj

Marques

et al. 2023

Crystal Growth & Design

View full text Add to dashboard Cite

show abstract

“…This method continues to pioneer unprecedented crystallization phenomena. Moreover, LTIC has advantages to precisely explore the fundamental process of crystallization because switchable crystallization/dissolution can be controlled and tracked in situ under a microscope coupled to a laser trapping system compared with nonphotochemical laser-induced nucleation (NPLIN) based on pulse laser irradiation. − …”

Section: Introductionmentioning

confidence: 99%

Plasmonic Manipulation of Sodium Chlorate Chiral Crystallization: Directed Chirality Transfer via Contact-Induced Polymorphic Transformation and Formation of Liquid Precursor

Niinomi

Sugiyama

Tagawa

et al. 2020

Crystal Growth & Design

Self Cite

View full text Add to dashboard Cite

The control of crystallization not only impacts the production of functional crystalline materials or pharmaceuticals but also provides profit to investigate the fundamental mechanism of crystallization. Recently, we have revealed that plasmonic optical tweezers (POT) can “manipulate” the crystallization of a pharmaceutical compound from its aqueous solution by optically trapping molecular clusters, offering a novel strategy to control crystallization. Here we report a variety of unique crystallization phenomena by applying POT to sodium chlorate (NaClO3) chiral crystallization from an aqueous microdroplet loaded on a plasmonic substrate. Plasmon excitation significantly promotes crystallization intermediated by an achiral metastable crystal as a precursor. Also, the direction of the creeping of the resulting chiral crystal can be controlled. By utilizing this phenomenon, we achieved the directed chirality transfer from the chiral crystal to the achiral crystal via a forced contact-induced polymorphic transformation by intentionally making creeping chiral crystal contact with an achiral crystal. Moreover, we captured, by in situ optical microscopic observation, a liquid precursor that intermediates the NaClO3 achiral crystallization for the first time. Our results highlight the plasmonic manipulation of crystallization opening a new door not only to control crystallization but also to investigate the unprecedented fundamental process of crystallization.

show abstract

“…LTIC has also been reported for undersaturated solutions of glycine in D 2 O 104 and L-Phenylalanine in H 2 O. 128 8. Phase-separated liquid-like droplets have been observed in LTIC experiments prior to crystallization.…”

Section: Discussionmentioning

confidence: 75%

A review on laser-induced crystallization from solution

Vikram¹,

Nagaraj²,

Marques³

et al. 2023

Preprint

View full text Add to dashboard Cite

Crystallization is abound in nature and industrial practice. A plethora of indispensable products ranging from agrochemicals and pharmaceuticals to battery materials, are produced in crystalline form in industrial practice. Yet, our control over the crystallization process across scales, from molecular to macroscopic, is far from complete. This bottleneck not only hinders our ability to engineer the properties of crystalline products essential for maintaining our quality of life but also hampers progress toward a sustainable circular economy in resource recovery. In recent years, approaches leveraging light fields have emerged as promising alternatives to manipulate crystallization. In this review article, we classify laser-induced crystallization approaches where light-material interactions are utilized to influence crystallization phenomena according to proposed underlying mechanisms and experimental setups. We discuss non-photochemical laser-induced nucleation, high-intensity laser-induced nucleation, laser trapping-induced crystallization, and indirect methods in detail. Throughout the review, we highlight connections amongst these separately evolving sub-fields to encourage interdisciplinary exchange of ideas.

show abstract

In situ reflection imaging and microspectroscopic study on three-dimensional crystal growth of L-phenylalanine under laser trapping

Cited by 5 publications

References 31 publications

A Review of Laser-Induced Crystallization from Solution

A Review of Laser-Induced Crystallization from Solution

Plasmonic Manipulation of Sodium Chlorate Chiral Crystallization: Directed Chirality Transfer via Contact-Induced Polymorphic Transformation and Formation of Liquid Precursor

A review on laser-induced crystallization from solution

Contact Info

Product

Resources

About