In situ structural and microangiographic assessment of human skin lesions with high-speed OCT

Blatter, Cédric; Weingast, Jessika; Alex, Aneesh; Grajciar, Branislav; Wieser, Wolfgang; Drexler, Wolfgang; Huber, Robert; Leitgeb, Rainer A.

doi:10.1364/boe.3.002636

Cited by 117 publications

(95 citation statements)

References 27 publications

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“…Recent results of OCT angiography indicated that alterations of the vascular pattern are characteristic for different pathologic conditions, such as inflammation, or skin cancer. 147 The expectations to use functional OCT for enhanced diagnosis in dermatology are, therefore, high.…”

Section: Label-free Optical Angiographymentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

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432

264

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Abstract. In the last 25 years, optical coherence tomography (OCT) has advanced to be one of the most innovative and most successful translational optical imaging techniques, achieving substantial economic impact as well as clinical acceptance. This is largely owing to the resolution improvements by a factor of 10 to the submicron regime and to the imaging speed increase by more than half a million times to more than 5 million A-scans per second, with the latter one accomplished by the state-of-the-art swept source laser technologies that are reviewed in this article. In addition, parallelization of OCT detection, such as line-field and full-field OCT, has shortened the acquisition time even further by establishing quasi-akinetic scanning. Besides the technical improvements, several functional and contrast-enhancing OCT applications have been investigated, among which the label-free angiography shows great potential for future studies. Finally, various multimodal imaging modalities with OCT incorporated are reviewed, in that these multimodal implementations can synergistically compensate for the fundamental limitations of OCT when it is used alone. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Label-free Optical Angiographymentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

Self Cite

432

264

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“…Angiographic OCT based on flow characteristics provides additional vascular information within tissue, such as diameter, shape and distribution of blood vessels and their perfusion. Angiographic OCT has been applied to detecting abnormal vasculature of skin lesions such as port-wine stain (PWS) and basal cell carcinoma (BCC) [24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Dermoscopy guided dark-field multi-functional optical coherence tomography

Kwon

Yoon

Kim

et al. 2017

Biomed. Opt. Express

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Dermoscopy is a skin surface microscopic technique allowing specular reflection free observation of the skin, and has been used to examine pigmented skin lesions. However, dermoscopy has limitations in providing depth information due to lack of 3D resolution. In order to overcome the limitations, we developed dermoscopy guided multi-functional optical coherence tomography (MF-OCT) providing both high-contrast superficial information and depth-resolved structural, birefringent, and vascular information of the skin simultaneously. Dermoscopy and MF-OCT were combined by using a dichroic mirror, and dark-field configuration was adapted for MF-OCT to reduce specular reflection. After characterization, dermoscopy guided MF-OCT was applied to several human skin lesions such as the scar, port-wine stain (PWS) as well as the normal skin for demonstration. Various features of the scar and PWS were elucidated by both dermoscopy and MF-OCT. Dermoscopy guided MF-OCT may be useful for evaluation and treatment monitoring of skin lesions in clinical applications. Reinhold, "The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of nonpigmented basal cell carcinoma: an observational study," Br. J. Dermatol. 173(2), 428-435 (2015). 28. A. J. Coleman, G. P. Penney, T. J. Richardson, A. Guyot, M. J. Choi, N. Sheth, E. Craythorne, A. Robson, and R. Mallipeddi, "Automated registration of optical coherence tomography and dermoscopy in the assessment of sub-clinical spread in basal cell carcinoma," Comput.

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“…The functional extension of OCT angiography contrasts specifically blood flow against static tissue based on signal decorrelation without the need of contrast agents, thereby providing microvascular details with high contrast in strongly scattering tissue that are not visible with standard OCT [12]. OCT angiography has been applied to image facial or palmar human skin [13][14][15]. But even with focus field extension using Bessel beams or contrast enhancement algorithms to reduce the residual static artifacts, the effective angiographic imaging depth is well below 2 mm.…”

Section: Introductionmentioning

confidence: 99%

Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging

Chen

Zabihian

et al. 2016

Biomed. Opt. Express

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Cutaneous blood flow accounts for approximately 5% of cardiac output in human and plays a key role in a number of a physiological and pathological processes. We show for the first time a multi-modal photoacoustic tomography (PAT), optical coherence tomography (OCT) and OCT angiography system with an articulated probe to extract human cutaneous vasculature in vivo in various skin regions. OCT angiography supplements the microvasculature which PAT alone is unable to provide. Co-registered volumes for vessel network is further embedded in the morphologic image provided by OCT. This multi-modal system is therefore demonstrated as a valuable tool for comprehensive non-invasive human skin vasculature and morphology imaging in vivo.

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In situ structural and microangiographic assessment of human skin lesions with high-speed OCT

Cited by 117 publications

References 27 publications

Optical coherence tomography today: speed, contrast, and multimodality

Optical coherence tomography today: speed, contrast, and multimodality

Dermoscopy guided dark-field multi-functional optical coherence tomography

Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging

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