In Systemic Sclerosis, Anxiety and Depression Assessed by Hospital Anxiety Depression Scale Are Independently Associated with Disability and Psychological Factors

Rosso, Angela Del; Mikhaylova, Svetlana; Baccini, Marco; Lupi, Ilaria; Cerinic, Marco Matucci; Bongi, Susanna Maddali

doi:10.1155/2013/507493

Cited by 31 publications

(31 citation statements)

References 45 publications

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“…Our study sample is small and there for has limited power to detect a difference. Only one individual was borderline for symptoms of depression at baseline which is significantly lower than the 23% with high depression reported in the German control sample (Crawford et al, 2001; Del Rosso et al, 2013; Hinz & Brahler, 2011; Watkins et al, 2013). These data suggest that the subgroup electing to proceed with the testing may be self-selecting as has been observed previously in the HD population (Codori et al, 1994; Kessler, 1994; Tyler et al, 1992).…”

Section: Discussioncontrasting

confidence: 62%

Psychological Impact of Predictive Genetic Testing in VCP Inclusion Body Myopathy, Paget Disease of Bone and Frontotemporal Dementia

Surampalli

Khare

Kubrussi

et al. 2015

Journal of Genetic Counseling

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Inclusion Body Myopathy associated with Paget’s disease of Bone and Fronto-temporal Dementia, also known as multisystem proteinopathy is an autosomal dominant, late onset neurodegenerative disorder caused by mutations in Valosin containing protein (VCP) gene. This study aimed to assess uptake and decision making for predictive genetic testing and the impact on psychological well-being. Individuals who had participated in the gene discovery study with a 50% a priori risk of inheriting VCP disease were sent a letter of invitation offering genetic counseling and testing and were also invited to participate in this psychosocial study. A total of 102 individuals received an invitation and 33 individuals participated in genetic counseling and testing (32.3%) with 29 completing baseline questionnaires. Twenty completed the follow-up post-test Hospital Anxiety and Depression Scale questionnaire including 13 who had tested positive. Mean risk perception at baseline was 50.1%. Reasons for testing included planning for the future, relieving uncertainty, informing children and satisfying curiosity. At baseline, one quarter of the participants had high levels of anxiety. However, scores were normal one year following testing. In this small cohort, one third of individuals at 50% risk chose pre-symptomatic testing. Although one quarter of those choosing testing had high anxiety at baseline, this was not evident at follow-up.

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Section: Discussioncontrasting

confidence: 62%

Psychological Impact of Predictive Genetic Testing in VCP Inclusion Body Myopathy, Paget Disease of Bone and Frontotemporal Dementia

Surampalli

Khare

Kubrussi

et al. 2015

Journal of Genetic Counseling

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“…The on December 1, 2014 -Published by www.jrheum.org Downloaded from Depression was also associated with disability in systemic sclerosis 33 and multiple sclerosis 34 .…”

Section: Journal Of Rheumatologymentioning

confidence: 90%

Predictors of Incident Depression in Systemic Lupus Erythematosus

Huang

Magder²,

Petri³

2014

J Rheumatol

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Depression in SLE is multifactorial. Higher-dose prednisone (≥ 20 mg daily) is 1 important independent risk factor. Global disease activity is not a risk factor, but cutaneous activity and certain types of neurologic activity (myelitis) are predictive of depression. The independent effect of prednisone provides clinicians with an additional incentive to avoid and reduce high-dose prednisone exposure in SLE.

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“…Chronic pain can independently contribute to the pathogenesis of depression, through elevation of inflammatory cytokines IL‐1β, IL‐6, and TNF‐α . Here, we review the prevalence and characteristics of depression, and its correlation to the levels of inflammatory cytokines and disease activity among different CTD (Tables and ).…”

Section: Depression In Connective Tissue Diseasesmentioning

confidence: 99%

Cytokine secretion and the risk of depression development in patients with connective tissue diseases

Grygiel-Górniak

Limphaibool

Puszczewicz

2019

Psychiatry Clin Neurosci

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Research in the past two decades has revolutionized our understanding of depressive illnesses. Proinflammatory cytokines have become a point of interest in the interconnecting areas of neuropsychiatric and autoimmune diseases. The cytokine hypothesis of depression suggests that pro‐inflammatory cytokines play a primary role in the mediation of the pathophysiological characteristics of major depression, in which an inflammatory process may be induced by external and internal stressors, such as psychological and inflammatory diseases, respectively. The higher prevalence of depression, particularly in patients with chronic autoimmune connective tissue disorders (CTD), suggests that depression may present a dysfunctional adaptation of cytokine‐induced sickness, which could manifest in times of an exacerbated activation of the innate immune system. Inflammation is thought to contribute to the development of clinical depression through its ability to induce sickness behaviors corresponding to the neurovegetative features of depression, through the dysregulation of the hypothalamic–pituitary–adrenal axis, alterations in neurotransmitter synthesis and reuptake, and through its involvement in the neuroprogression pathways. This review explores the complex interrelationships in which inflammatory responses alter neuroendocrine and neuropsychological regulation contributing to depressive symptoms in CTD. The prevalence and characteristics of depression, and its correlation to the levels of inflammatory cytokines and disease activity among different CTD will be reviewed.

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In Systemic Sclerosis, Anxiety and Depression Assessed by Hospital Anxiety Depression Scale Are Independently Associated with Disability and Psychological Factors

Cited by 31 publications

References 45 publications

Psychological Impact of Predictive Genetic Testing in VCP Inclusion Body Myopathy, Paget Disease of Bone and Frontotemporal Dementia

Psychological Impact of Predictive Genetic Testing in VCP Inclusion Body Myopathy, Paget Disease of Bone and Frontotemporal Dementia

Predictors of Incident Depression in Systemic Lupus Erythematosus

Cytokine secretion and the risk of depression development in patients with connective tissue diseases

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