In utero single low-dose exposure of cadmium induces rat fetal Leydig cell dysfunction

Li, Xiaojun; Liu, Jianpeng; Wu, Siwen; Zheng, Wenwen; Li, Huitao; Bao, Suhao; Chen, Yong; Guo, Xinhong; Zhang, Lei; Ge, Ren‐Shan

doi:10.1016/j.chemosphere.2017.11.159

Cited by 27 publications

(15 citation statements)

References 42 publications

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“…We measured serum testosterone levels by immunochemiluminometric assay using the IMMULITE ® 2000 Immunoassay Kit (Sinopharm, Hangzhou, China) as previously described (Li et al, 2018). The minimal detection limit of testosterone was 0.2 ng per mL.…”

Section: Methodsmentioning

confidence: 99%

In utero Exposure to Atrazine Disrupts Rat Fetal Testis Development

Fang

Dong

et al. 2018

Front. Pharmacol.

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Atrazine (ATR) is a commonly used agricultural herbicide and a potential endocrine disruptor that may cause testicular dysgenesis. The objective of the present study was to investigate the effects of atrazine on fetal testis development after in utero exposure. Female Sprague-Dawley rats were gavaged daily with vehicle (corn oil, control) or atrazine (25, 50, and 100 mg/kg body weight/day) from gestational day 12 to 21. Atrazine dose-dependently decreased serum testosterone levels of male pups, with a significant difference from the control recorded at a dose of 100 mg/kg. In addition, atrazine significantly increased fetal Leydig cell aggregation at a dose of 100 mg/kg. Atrazine increased fetal Leydig cell number but not Sertoli cell number. However, atrazine down-regulated Scarb1 and Cyp17a1 in the fetal Leydig cell per se and Hsd17b3 and Dhh in the Sertoli cell per se. These results demonstrated that in utero exposure to atrazine disrupted rat fetal testis development.

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Section: Methodsmentioning

confidence: 99%

In utero Exposure to Atrazine Disrupts Rat Fetal Testis Development

Fang

Dong

et al. 2018

Front. Pharmacol.

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“…A single intraperitoneal injection (ip.) of low doses of Cd to rats on GD12 down-regulates the expression of SC genes (Dhh and Fshr), although this does not affect its number (Li et al, 2018). Exposure to Cd (1-2 mg/kg, sc) in pregnant and lactating rats can cause vacuolation of SCs and loss of Mckenna et al, 1996;Waalkes et al, 1997Waalkes et al, , 1999Biswas et al, 2001;Gunnarsson et al, 2004;Blanco et al, 2007Blanco et al, , 2010Cupertino et al, 2017;Wu et al, 2017;Mahmoudi et al, germ cells in adult seminiferous epithelium (Bekheet, 2011).…”

Section: Effects Of CD On Sertoli Cells (Scs)mentioning

confidence: 99%

“…Pregnant rats receiving a single dose of Cd (0.25, 0.5, and 1.0 mg/kg, i.p.) can remarkably decrease T synthesis of the fetal testis, lower FLC number, down-regulate the expression of FLC genes (Lhcgr, Scarb1, Star, Cyp11a1, Hsd3b1, and Cyp17a1) of male offspring (Li et al, 2018) and it also shortens the anogenital distance, an androgen-dependent process, of male offspring (Li et al, 2018). In the testis of rats that are perinatally (during gestation and lactation) exposed to Cd and the development of ALCs is delayed, with an increase in the number of ILCs (Srd5a1-expressing cells), and decrease in cAMP/PKA signaling and down-regulation of T steroidogenic enzymes (Tian et al, 2018).…”

Section: Mechanisms Of Cadmium-mediated Action the Endocrine-disruptimentioning

confidence: 99%

Toxicological Effects of Cadmium on Mammalian Testis

Zhu

2020

Front. Genet.

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Cadmium is a heavy metal, and people are exposed to it through contaminated foods and smoking. In humans and other mammals, cadmium causes damage to male testis. In this review, we summarize the effects of cadmium on the development and function of the testis. Cadmium causes severe structural damage to the seminiferous tubules, Sertoli cells, and blood-testis barrier, thus leading to the loss of sperm. Cadmium hinders Leydig cell development, inhibits Leydig cell function, and induces Leydig cell tumors. Cadmium also disrupts the vascular system of the testis. Cadmium is a reactive oxygen species inducer and possibly induces DNA damage, thus epigenetically regulating somatic cell and germ cell function, leading to male subfertility/infertility.

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“…Among theses One important by-product toxicant is Cadmium (Cd), featured by its solubility in water, transferability, persistence and durability, universality, and severe toxicity (Li et al, 2015). Because of these properties, Cd is reported as the sixth most dangerous chemical for living things by the Agency of Toxic substances and Disease Registry (ATSDR) (Li et al, 2018;Ramelli et al, 2009;Zhang et al, 2017). Despite these hazardous features of Cd and warning of ATSDR, the world health organization (WHO) reported that the quantity of Cd is increasing with human activities and accumulate in the air, soil, and water (WHO, 1960;Krzyzanowski and Cohen, 2008;Ramelli et al, 2009;Trejo et al, 2016) resulting in its adsorption by plants, which is diet source for human and animals (Rafati Rahimzadeh et al, 2017;Faroon et al, 2012;Järup and Åkesson, 2009;Ramelli et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Ameliorative effects of morel mushroom (Morchella esculenta) against Cadmium-induced reproductive toxicity in adult male rats

et al. 2022

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Cadmium (Cd) is one of the major toxicants, which affects human health through occupational and environmental exposure. In the current study, we evaluated the protective effects of morel mushrooms against Cd-induced reproductive damages in rats. For this purpose, 30 male rats were divided into 6 groups (n=5/group), the first group served as the control group, second group was treated with an intraperitoneal (i.p) injection of 1 mg/kg/day of Cd. Third and fourth groups were co-treated with 1 mg/kg/day of Cd (i.p) and 10 and 20 mg/kg/day of morel mushroom extract (orally) respectively. The final 2 groups received oral gavage of 10 and 20 mg/kg/day of morel mushroom extract alone. After treatment for 17 days, the animals were euthanized, and testes and epididymis were dissected out. One testis and epididymis of each animal were processed for histology, while the other testis and epididymis were used for daily sperm production (DSP) and comet assay. Our results showed that Cd and morel mushrooms have no effect on animal weight, but Cd significantly decreases the DSP count and damages the heritable DNA which is reversed in co-treatment groups. Similarly, the histopathological results of testes and epididymis show that morel mushrooms control the damage to these tissues. Whereas the morel mushroom extract alone could enhance the production of testosterone. These results conclude that morel mushrooms not only control the damage done by Cd, but it could also be used as a protection mechanism for heritable DNA damage.

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In utero single low-dose exposure of cadmium induces rat fetal Leydig cell dysfunction

Cited by 27 publications

References 42 publications

In utero Exposure to Atrazine Disrupts Rat Fetal Testis Development

In utero Exposure to Atrazine Disrupts Rat Fetal Testis Development

Toxicological Effects of Cadmium on Mammalian Testis

Ameliorative effects of morel mushroom (Morchella esculenta) against Cadmium-induced reproductive toxicity in adult male rats

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