2024
DOI: 10.1002/ddr.22184
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In vitro and in silico investigation of FDA‐approved drugs to be repurposed against Alzheimer's disease

Didem Akkaya,
Gökçe Seyhan,
Suat Sari
et al.

Abstract: Alzheimer's disease (AD), one of the main causes of dementia, is a neurodegenerative disorder. Cholinesterase inhibitors are used in the treatment of AD, but prolonged use of these drugs can lead to serious side effects. Drug repurposing is an approach that aims to reveal the effectiveness of drugs in different diseases beyond their clinical uses. In this work, we investigated in vitro and in silico inhibitory effects of 11 different drugs on cholinesterases. The results showed that trimebutine, theophylline, … Show more

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