In vitro and in vivo evaluation of anti-arthritic, antioxidant efficacy of fucoidan from Undaria pinnatifida (Harvey) Suringar

Phull, Abdul Rehman; Majid, Muhammad; Haq, Ihsan‐ul; Khan, Muhammad Rashid; Kim, Song Ja

doi:10.1016/j.ijbiomac.2017.01.051

Cited by 120 publications

(73 citation statements)

References 59 publications

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“…In the present study, marked reduction in the antioxidant system (SOD, CAT, GPx and GSH) in CCl 4 treated groups was observed when compared with the control group. Depletion of the antioxidant system in CCl 4 treated group could be attributed to CCl 4 generated cellular ROS production and the subsequent depletion of the antioxidant cellular system [27][28][29][30][31][32][33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Attenuation of CCl4 Induced Oxidative Stress, Immunosuppressive, Hepatorenal Damage by Fucoidan in Rats

El‐Boshy¹,

Abdelhamidb²,

Richab³

et al. 2017

J Clinic Toxicol

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The protective and therapeutic effects of fucoidan extract from Laminaria species against liver damage induced by CCl 4 in rats was investigated by monitoring the serum level and hepatic m-RNA expression of TGFβ-1, liver and renal markers, as well as oxidative stress and antioxidant biomarker. Thirty six adult male albino rats were divided into 4 equal groups; one was used as a negative control while groups II, III, and IV administrated 0.1 mL/100 g body weight twice a week for 8 weeks with carbon tetrachloride (CCl 4 ), fucoidan (400 mg/kgbw orally/day), and CCl 4 plus fucoidan, respectively. Blood samples were collected at the end of experiment and sera were separated to evaluate serum levels and the hepatic m-RNA expression of transforming growth factor beta (TGFβ-1), tumor necrosis factor (TNF α), interferon gamma (IFN-γ.), interleukin (IL), Il-1β, IL-6 and IL-10, antioxidant markers, reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and lipid peroxidation malondialdehyde (MDA) as well as selective biochemical markers of liver and kidney functions were estimated. The results of this investigation revealed that treatment with fucoidan improved elevated expression of liver TGF β-1, Il-1β, IL-6, TNF α and serum level of malnoaldehyde (MDA), total bilirubin (T. Bil), induced by CCl 4 at 8th week post treatment. In addition to enhancing the antioxidant enzyme activities, GSH, GPx, CAT and SOD. Also, liver trransaminase (ALT, AST), alkaline phosphatase (ALP), reduced in fucoidan and CCl 4 treated group. These results show that crude fucoidan has potential immunomodulatory, antioxidant and hepatoprotective effects against the hepatic damage induced by CCl 4 .

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Section: Discussionmentioning

confidence: 99%

Attenuation of CCl4 Induced Oxidative Stress, Immunosuppressive, Hepatorenal Damage by Fucoidan in Rats

El‐Boshy¹,

Abdelhamidb²,

Richab³

et al. 2017

J Clinic Toxicol

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“…7 contain as an active anti-pollution ingredient Undaria pinnatifida extract; this brown alga is widely used as food and as a remedy in traditional Chinese medicine for over 1000 years. As stated previously for brown algae, U. pinnatifida contains sulfated polysaccharides that exhibit good antioxidant activities, related with their sulfate content [54,60]. Moreover, it also contains fucoxanthin, a carotenoid present in the chloroplasts, able to counteract oxidative stress by UV radiation [61].…”

Section: Anti-pollution Ingredients From Algaementioning

confidence: 80%

“…Fucoidans exhibit a broad spectrum of biological activities, including anticancer, apoptosis-inducing, immunomodulatory, antiviral, anti-thrombotic, anti-inflammatory and antioxidant activities [51]. In vitro antioxidant activity of fucoidans has been determined by various methods, such as DPPH free radical scavenging assay, iron-chelating activity assessment, superoxide anion and hydroxyl radical scavenging activity, reducing power assay [50,[52][53][54]. Recently, effective methods of extraction of fucoidans (microwave-assisted extraction, high pressure homogenization combined with hydrothermal extraction), alternative to classical extraction methods (hot water, diluted acid, diluted alkali), time-expensive and associated to multi-step processes, high temperature, large solvent volumes, were developed [50,53].…”

Section: Anti-pollution Ingredients From Algaementioning

confidence: 99%

Cosmetic Functional Ingredients from Botanical Sources for Anti-Pollution Skincare Products

Juliano

Magrini

2018

Cosmetics

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Air pollution is a rising problem in many metropolitan areas around the world. Airborne contaminants are predominantly derived from anthropogenic activities, and include carbon monoxide, sulfur dioxide, nitrogen oxides, volatile organic compounds, ozone and particulate matter (PM; a mixture of solid and liquid particles of variable size and composition, able to absorb and delivery a large number of pollutants). The exposure to these air pollutants is associated to detrimental effects on human skin, such as premature aging, pigment spot formation, skin rashes and eczema, and can worsen some skin conditions, such as atopic dermatitis. A cosmetic approach to this problem involves the topical application of skincare products containing functional ingredients able to counteract pollution-induced skin damage. Considering that the demand for natural actives is growing in all segments of global cosmetic market, the aim of this review is to describe some commercial cosmetic ingredients obtained from botanical sources able to reduce the impact of air pollutants on human skin with different mechanisms, providing a scientific rationale for their use.

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“…Fucoidan is a fucose-rich sulfated polysaccharide found in various species of brown seaweed (4)(5)(6)(7). Fucoidan has been shown to exert various biological activities, including antioxidant, anti-inflammatory, anti-angiogenic, anti-coagulant, anti-bacterial, and anticancer effects (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Studies have shown anticancer activities of fucoidan in lung, breast, liver, colon, prostate, and bladder cancer cells (19)(20)(21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

Fucoidan downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells

Kim

Nam

2018

Oncol Rep

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Fucoidan, a sulfated polysaccharide present in brown seaweed, has demonstrated anticancer activity in lung, breast, liver and colon cells. The insulin-like growth factor (IGF) signaling pathway regulates growth in HT-29 cells through the insulin receptor substrate-1 (IRS-1)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and Ras/Raf/extracellular signal-regulated kinase (ERK) pathways. The aim of the present study was to investigate whether fucoidan downregulates the IGF-IR signaling pathway in HT-29 human colon cancer cells. Fucoidan treatment (0-1,000 µg/ml) was administered for 24 h in HT-29 cells. First, we investigated IRS-1/PI3K/AKT pathway-related protein expression levels following treatment with fucoidan (0-500 µg/ml) using western blot analysis. Fucoidan significantly inhibited the expression of IGF-IR, PTEN, PI3K and AKT as well as their phosphorylated forms (p-IRS-1, p-PI3K and p-AKT). Next, we investigated the effects of fucoidan on Ras/Raf/ERK pathway‑related protein expression levels in HT-29 cells. Fucoidan significantly inhibited the expression of IGF-IR, Shc, Ras, SOS, Raf and MEK. HT-29 cells were then incubated in the presence of fucoidan (0 or 250 µg/ml), and IGF-I (10 nM) was added for 0 to 60 min. Immunoprecipitation (IP) experiments showed that fucoidan inhibited IGF-I-induced phosphorylation of IGF-IR, PI3K, Shc (IP, IGF-IR), and phosphorylated IRS-1 and PI3K (IP, IRS-1) compared to the control group. Western blot analysis showed that fucoidan inhibited the expression of IGF-I-induced p-IGF-IR/IGF-IR and p-AKT/AKT, but not p-ERK/ERK. In conclusion, the inhibition of cell viability by fucoidan in HT-29 cells may be due to the downregulation of IGF-IR signaling through the main IRS-1/PI3K/AKT pathway. Fucoidan also partially impacted Ras/Raf signaling in the Ras/Raf/ERK pathway. Therefore, we suggest that fucoidan may be a suitable candidate chemopreventive agent in HT-29 colon cancer cells.

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In vitro and in vivo evaluation of anti-arthritic, antioxidant efficacy of fucoidan from Undaria pinnatifida (Harvey) Suringar

Cited by 120 publications

References 59 publications

Attenuation of CCl4 Induced Oxidative Stress, Immunosuppressive, Hepatorenal Damage by Fucoidan in Rats

Attenuation of CCl4 Induced Oxidative Stress, Immunosuppressive, Hepatorenal Damage by Fucoidan in Rats

Cosmetic Functional Ingredients from Botanical Sources for Anti-Pollution Skincare Products

Fucoidan downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells

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