In vitro and in vivo anti-inflammatory properties of green synthesized silver nanoparticles using Viburnum opulus L. fruits extract

Moldovan, Bianca; David, Luminiţa; Vulcu, Adriana; Olenic, Liliana; Perde-Schrepler, Maria; Fischer‐Fodor, Eva; Bâldea, Ioana; Clichici, Simona; Filip, Gabriela Adriana

doi:10.1016/j.msec.2017.05.122

Cited by 87 publications

(27 citation statements)

References 47 publications

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“…When treated with VmNPs, HaCaT cells showed weak cytotoxicity (78.04%, 76.56%, 75.28%, and 72.67%) at high concentrations (250, 500, 750, and 1000 µg/mL, respectively) and at the same concentrations, A375 cells showed moderate (47.25% at 250 µg/mL and 40.77% at 1000 µg/mL) and strong (35.87% at 500 µg/mL and 37.92% at 750 µg/mL) cytotoxicity ( Figure 7). Low to no cytotoxicity on HaCaT was observed by other researchers also [64,65], and negative effect on A375 cells produced by green synthesized AgNPs was reported before [66,67]. In our study, A375 cells were significantly (p < 0.0001) more affected than HaCaT cells by VmNPs concentrations, with the lowest viability value (35.87%) registered at 500 µg/mL.…”

Section: Mtt Assaysupporting

confidence: 65%

Green Synthesis of Ag-MnO2 Nanoparticles using Chelidonium majus and Vinca minor Extracts and Their In Vitro Cytotoxicity

et al. 2020

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Medicinal plants are often used as reducing agents to prepare metal nanoparticles through green-synthesis due to natural compounds and their potential as chemotherapeutic drugs. Thus, three types of eco-friendly Ag-MnO2 nanoparticles (Ag-MnO2NPs) were synthesized using C. majus (CmNPs), V. minor (VmNPs), and a 1:1 mixture of the two extracts (MNPs). These NPs were characterized using S/TEM, EDX, XRD, and FTIR methods, and their biological activity was assessed in vitro on normal keratinocytes (HaCaT) and skin melanoma cells (A375). All synthesized NPs had manganese oxide in the middle, and silver oxide and plant extract on the exterior. The NPs had different forms (polygonal, oval, and spherical), uniformly distributed, with crystalline structures and different sizes (9.3 nm for MNPs; 10 nm for VmNPs, and 32.4 nm for CmNPs). The best results were obtained with VmNPs, which reduced the viability of A375 cells up 38.8% and had a moderate cytotoxic effect on HaCaT (46.4%) at concentrations above 500 µg/mL. At the same concentrations, CmNPs had a rather proliferative effect, whereas MNPs negatively affected both cell lines. For the first time, this paper proved the synergistic action of the combined C. majus and V. minor extracts to form small and uniformly distributed Ag-MnO2NPs with high potential for selective treatments.

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Section: Mtt Assaysupporting

confidence: 65%

Green Synthesis of Ag-MnO2 Nanoparticles using Chelidonium majus and Vinca minor Extracts and Their In Vitro Cytotoxicity

et al. 2020

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“…The peak at 1726 cm −1 is due to carbonyl stretching vibration while the peak at 1651 cm −1 can be attributed to C]C stretching vibration. The peak at 1289 cm −1 corresponds to the CeO stretching vibration [48]. The peaks at 1545, 1068 cm −1 indicates the presence of aromatic and aliphatic amines respectively [49].…”

Section: Effect Of Different Parameters On the Synthesis Of Agnpsmentioning

confidence: 99%

Biosynthesis of silver nanoparticle using extract of Zea mays (corn flour) and investigation of its cytotoxicity effect and radical scavenging potential

Rajkumar

Sápi

Das

et al. 2019

Journal of Photochemistry and Photobiology B: Biology

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Silver nanoparticles (AgNPs) possesses a number of exceptional pharmaceutical properties and applications as compared with other types of metallic nanoparticles. Currently, AgNPs was biosynthesized using an aqueous extract of Zea mays L. (corn flour) powder. Further, the effect of concentration of reagents, extract, temperature and time of synthesis was also studied along with the cytotoxicity and radical scavenging potential. UV-vis spectra of AgNPs gave a surface plasmon resonance at~420 nm. The absorption peak became sharp with the increase in time. AgNPs with monodispersed and aggregated spherical shape was observed by SEM image followed by its confirmation via strong signal in silver region of EDX spectrum. The XRD spectra confirmed its crystallinity and face-centered cubic structure. FT-IR spectra reveal the presence of phytocompounds in the synthesis of AgNPs. Further, the AgNPs exhibited strong cytotoxicity potential against HepG2 cells and its viability declined with an increase in the concentration of AgNP with respect to the control cells. It also demonstrated reasonable radical scavenging potential in terms of DPPH and ABTS scavenging, and reducing power tests. Taken together, these results of the current investigation stated that AgNPs could be beneficial in biomedical applications particularly for treatment of cancer disease along with its applications in pharmaceutical industries for the formulation of new drugs.

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“…They are reported to possess a high anti-oxidative effect, especially due to their high amount of polyphenolics, anthocyanins and ascorbic acid [13][14][15][16]. The bioactive phytocomponents of European cranberry bush fruits were also reported to possess antimicrobial, antidiabetic, antihypertensive and anti-inflammatory effects [17][18][19]. The valuable antioxidant compounds of these fruits were already successfully exploited by our research group, to achieve the green synthesis of silver nanoparticles and their in vitro and in vivo anti-inflammatory activity was reported [17].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Biogenic Silver Nanoparticles for Efficient Catalytic Removal of Harmful Organic Dyes

2020

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The present article reports an environmentally benign method for synthesizing silver nanoparticles using the fruit extract of Viburnum opulus L. as a source of bioactive compounds, which can act as reducing agents of the silver ions and also as stabilizing agents of the obtained nanoparticles. The catalytic ability of the synthesized silver nanoparticles (AgNPs) to remove toxic organic dyes was also evaluated. The biosynthesis of silver nanoparticles was firstly confirmed by UV-Vis spectral analysis, which revealed the presence of the characteristic absorption peak at 415 nm corresponding to the surface plasmon vibration of colloidal silver. Fourier-transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA) studies were conducted to confirm the presence of bioactive phytocompounds, especially phenolics, as capping and stabilizing agents of the AgNPs. The size, morphology and crystalline nature of the synthesized AgNPs were investigated by transmission electron microscopy and X-ray diffraction techniques revealing that the obtained nanoparticles were spherical shaped, with an average diameter of 16 nm, monodispersed, face centered cubic nanoparticles. Further, the catalytic ability in the degradation of tartrazine, carmoisine and brilliant blue FCF dyes by NaBH4 was evaluated. The results demonstrated an efficient activity against all the investigated dyes being an outstanding catalyst for the degradation of brilliant blue FCF. This eco-friendly synthetic approach can generate new tools useful in environmental pollution control.

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In vitro and in vivo anti-inflammatory properties of green synthesized silver nanoparticles using Viburnum opulus L. fruits extract

Cited by 87 publications

References 47 publications

Green Synthesis of Ag-MnO2 Nanoparticles using Chelidonium majus and Vinca minor Extracts and Their In Vitro Cytotoxicity

Green Synthesis of Ag-MnO2 Nanoparticles using Chelidonium majus and Vinca minor Extracts and Their In Vitro Cytotoxicity

Biosynthesis of silver nanoparticle using extract of Zea mays (corn flour) and investigation of its cytotoxicity effect and radical scavenging potential

Green Synthesis of Biogenic Silver Nanoparticles for Efficient Catalytic Removal of Harmful Organic Dyes

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