Acne is one of the most troublesome, frustrating, and common skin-care problems for people around the world. Acne vulgaris is the most common disorder treated by dermatologists. Acne is a disease of pilosebaceous units characterized by the formation of open and closed comedones, papules, pustules, nodules, and cysts. This condi-tion can be correlated with Mukhadushika in Ayurveda. The incidence of Mukhadushika is increasing day by day due to the consumption of junk food, fast food, cold drinks, etc which leads to imbalances in Dosha. This case is an ideal example of Mukhadushika and is successfully managed with Ayurveda therapy. The patient was suffer-ing from acne on the face, reddish spots, itching & burning sensation over the facial skin along with pain for the last two years. Considering clinical features and Kapha, Vata, and Rakta involved in pathology; the patient was treated with oral administration of Triphala Guggulu and Panchtikta ghrita guggulu along with aragvadhadi kashaya, before food and Avipattikar churna after food, at night Triphala churna administrated orally. Along with external application (Lepa) of powder of Manjishtha, Lodhra, Haridra, and Nimbapatra on the face for two months. After 15 days Ushir powder was added in Lepa instead of Nimbapatra: considering a poor response to a burning sensation. Treatment continued for the next 15 days. At the end of treatment two months, there was complete disappearance of acne, and relief in itching, burning sensation, and pain. Significant improvement was also observed in discoloration over the face. Hence it was concluded that external application along with oral administration of Ayurveda drugs is highly effective in the management of Mukhadushika.