In vitro antimicrobial and brine shrimp lethality of Allophylus cobbe L.

Islam, Tofazzal; Ma, Noor; Karon, Bijoy; Rm, de Freitas

doi:10.4103/0974-8520.105256

Cited by 2 publications

(2 citation statements)

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“…Antimicrobials in the family Sapindaceae are mainly triterpene saponins and triterpenes the later soluble lipid. The petroleum ether of Allophylus cobbe (L.) Raeusch strongly inhibited the growth of Shigella sonnei, Salmonella paratyphi , and C. neoformans with the MIC values of 31.2 µg/mL [ 178 , 179 , 180 , 181 ]. The methanol extract of the leaves of Harpullia arborea (Blanco) Radlk repressed a broad-spectrum of bacteria and fungi [ 182 ] whereas the ethanol extract of leaves was active against HCV [ 183 ] on probable account of simple phenolic glycosides [ 184 ].…”

Section: Distribution Of Antibacterial Antifungal and Antiviral Princ...mentioning

confidence: 99%

Antimicrobial Secondary Metabolites from the Mangrove Plants of Asia and the Pacific

et al. 2022

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Microbes such as the White Spot Syndrome Virus account for severe losses in the shrimp farming industry globally. This review examines the literature on the mangrove plants of Asia and the Pacific with antibacterial, antifungal, or antiviral activities. All of the available data published on this subject were collected from Google Scholar, PubMed, Science Direct, Web of Science, ChemSpider, PubChem, and a library search from 1968 to 2022. Out of about 286 plant species, 119 exhibited antimicrobial effects, and a total of 114 antimicrobial natural products have been identified including 12 with MIC values below 1 µg/mL. Most of these plants are medicinal. The mangrove plants of Asia and the Pacific yield secondary metabolites with the potential to mitigate infectious diseases in shrimp aquaculture.

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Section: Distribution Of Antibacterial Antifungal and Antiviral Princ...mentioning

confidence: 99%

Antimicrobial Secondary Metabolites from the Mangrove Plants of Asia and the Pacific

et al. 2022

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“…Hot infusion of the root barks is also used for rheumatic pains. Recent scientific investigations suggest that Allophylus cobbe possesses strong antimicrobial (Islam et al, 2012), antiulcer (Dharmani et al, 2005) and anti-osteoporosis activities (Kumar et al, 2010). Previous phytochemical studies of the plant have reported the presence of several flavonoids such as quercetin, pinitol, luteolin 7-O-β-Dglucopyranoside, rutin and apigenin-4-O-β-D-glucoside (Kumar et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory, Analgesic and Antioxidant Activities of <i>Allophylus Cobbe</i> Leaves

Jain

Hossain²,

Fatema³

et al. 2014

American Journal of Pharmacology and Toxicology

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Allophylus cobbe L. Raeuschel (Family-Sapindaceae) is a medicinal plant used traditionally for the treatment of various health risks like pain, inflammation, ulcers and wounds in Bangladesh. This study determined the polyphenolic compounds and evaluated the analgesic, anti-inflammatory and antioxidant effects of the ethanol extract of Allophylus cobbe leaves. High Performance Liquid Chromatography (HPLC) analysis was used to determine the polyphenolic compounds present in the extract. The analgesic activity was evaluated by hot plate and acetic acid induced writhing in mice at two different doses of 250 and 500 mg kg −1 body weight. The extract was also investigated for the anti-inflammatory effect on rats at above mentioned doses using carrageenan induced rat paw edema method. The antioxidant potential of the extract was determined in terms of radical scavenging ability of the stable 1, 1-Diphenyl-2-Picrylhydrazyl (DPPH) free radical. Preliminary phytochemical analysis revealed the presence of alkaloids, flavonoids, tannins and glycosides in the extract. High Performance Liquid Chromatography (HPLC) analysis also confirmed the presence of polyphenolic compounds such as (+)-catechin hydrate, (-)-epicatechin, caffeic acid, p-coumaric acid and quercetin. The extract increased the licking time of hind paw when placed on a hot plate by 35.31% at 250 mg kg −1 dose which is comparable to the increase shown by diclofenac sodium (42.73%) at the 3rd h of study in hot plate test. Moreover, the extract also showed good analgesic effect in acetic acid induced writhing test. The percent inhibition of writhing response by the extract was 85.96 and 78.07% at 250 and 500 mg kg −1 doses respectively while that of the standard drug was 66.67%. Furthermore, the extract also reduced carrageenan induced paw edema formation; the most prominent inhibition was found to be 58.88% (250 mg kg −1 ) at the 3rd h of study. The DPPH radical scavenging activity of the extract increased markedly with increasing concentrations. At a concentration of 200 µg mL −1 , the scavenging activity of the ethanol extract (91.53% inhibition) was comparable to that of the standard ascorbic acid (99.3% inhibition). Our results suggest that Allophylus cobbe extract possesses significant antinociceptive, anti-inflammatory and free radical scavenging activities which may justify the folkloric use of the plant in several communities for conditions such as colic, fever, inflammatory rheumatic pains and other oxidative stress associated disorders.

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In vitro antimicrobial and brine shrimp lethality of Allophylus cobbe L.

Cited by 2 publications

References 4 publications

Antimicrobial Secondary Metabolites from the Mangrove Plants of Asia and the Pacific

Antimicrobial Secondary Metabolites from the Mangrove Plants of Asia and the Pacific

Anti-Inflammatory, Analgesic and Antioxidant Activities of <i>Allophylus Cobbe</i> Leaves

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