In vitro antimicrobial and molecular docking of dichloro substituted benzoxazole derivatives

Synthesis and Antimicrobial Activity of Amino Linked Heterocycles

“…1 revealed that Gram-positive bacteria were more susceptible towards the tested compounds than Gramnegative bacteria. The bis benzothiazolyl quinazolines (8) exhibited higher activity than bis benzoxazolyl quinazolines (7) and bis benzimidazolyl quinazolines (9). It was noticed that 8c and 8f having chloro and nitro substituent on the aromatic ring displayed greater activity particularly on Staphylococcus aureus.…”

“…3) Different azoles, benzoxazoles, benzothiazoles and benzimidazoles are associated with diverse pharmacological activities viz., analgesic, antituberculosis, 4) antimicrobial, 5,6) anti-inflammatory, antioxidant and antiviral. 7) Synthetic analogues possessing these core structures have considerable medicinal interest and are identified as the important heterocyclic motifs for the development of novel therapeutics. In continuation to extend our search for the development of a variety of heteroaromatics with different pharmacophoric units 8) the present work synthesis of amino linked benzoxazolyl/benzothiazolyl/benzimidazolyl quinazolines as antimicrobial precursors has been taken up.…”

Study of binding interaction between anthelmintic 2, 3-dihydroquinazolin-4-ones with bovine serum albumin by spectroscopic methods

“…Even though brominated compounds have variety of applications in industrial purposes, it is less frequently used as medicine. Therefore, anthelmintic activity [33] of the brominated series of 2, 3-dihydroquinazolin-4(1H)-ones were carried out in this study. Also the interaction of the bioactive compound among the synthesized derivatives 2(a-i) with BSA were studied by fluorescence quenching, excitation emission spectra (EEM) spectra and circular dichroism (CD) spectroscopy.…”

Synthesis and Characterization of Novel Thiazole Anchored Pyrazolyl Benzoxazoles

“…Benzoxazole derivatives exhibits anthelmintic 1 , antiulcer 2 , antitumor 3 , antimicrobial 4,5 andanticancer 6 activities. Benzoxazole containing compounds are also acts as RSK2 inhibitor 7 and  1 -AR antagonist 8 .…”