In vitro antimicrobial synergism within plant extract combinations from three South African medicinal bulbs

Ncube, Bhekumthetho; Finnie, J.F.; Staden, J. Van

doi:10.1016/j.jep.2011.10.025

Cited by 96 publications

(62 citation statements)

References 28 publications

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“…Most of the research reviewed here shows that whole plant extracts or combinations of compounds are more effective antimicrobials than isolated constituents (Junio et al, 2012), (Lee and Lee, 2010), (Ncube et al, 2012), (Wang et al, 2013) and (Garvey et al, 2011).…”

Section: Discussionmentioning

confidence: 98%

“…In this review, antibacterial synergy was reported for Olea europea (Lee and Lee, 2010), Hydrastis canadensis (Junio et al, 2012), Tulbaghia violacea, Hypoxis hemerocallidea and Merwilla plumbea (Ncube et al, 2012) and Sophora moorcroftiana (Wang et al, 2013). Antibacterial synergy between plants and antibiotics was reported for: Rhus coriara (Adwan, et al, 2010), the polyphenol theaflavin (Betts, et al, 2012), Melissa officinalis and Levisticum officinale (Garvey et al, 2011).…”

Section: Synergy Directed Fractionationmentioning

confidence: 97%

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Antimicrobial resistance and synergy in herbal medicine

Mundy

Pendry

Rahman

2016

Journal of Herbal Medicine

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Antimicrobial resistance (AMR) is a serious and growing threat to human health. The development of new antibiotics is limited and slow. The tradition of synergy in herbal medicine is being used as a source of research ideas. A literature review of antimicrobial research and plant synergy published in a five year period was carried out using online databases. The in vitro findings were that most of the research reported synergy both within plants and between plants and antibiotics.Whole plant extracts and combinations of compounds were shown to be more effective antimicrobials than isolated constituents. The discussion highlights that the in vitro herbal research findings are difficult to apply to practice and aren't progressing to clinical trials.Collaborative, innovative, inter-disciplinary clinical research is recommended.

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Section: Discussionmentioning

confidence: 98%

Section: Synergy Directed Fractionationmentioning

confidence: 97%

Antimicrobial resistance and synergy in herbal medicine

Mundy

Pendry

Rahman

2016

Journal of Herbal Medicine

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“…The capacity of plants to complete combinatorial chemistry by mixing, coordinating and developing the quality items required for secondary metabolite biosynthetic pathways, makes a boundless pool of chemicals, which people have abused to their advantage. Consequently, the utilization of plants by people in both conventional and present day therapeutic frameworks, in this manner, to a great extent utilize this standard [8].…”

Section: Introductionmentioning

confidence: 99%

Preliminary Phytochemical Screening and in Vitro Antimicrobial Activity of Ethanolic Extract of Whole Aerial Part of the Herb Leucas Plukenetii Spreng (Family-Laminaceae)

Borah¹,

Dash²,

Dash³

et al. 2017

Int J Curr Pharm Sci

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Objective: To evaluate the antimicrobial activity of ethanolic extract of Leucas Plukenetii Spreng (family-laminaceae) in conjugation with phytochemical analysis. Methods:The ethanolic extract of whole aerial parts of the herb Leucas Plukenetiispreng (family-laminaceae) was prepared and analysed for phytochemical constituents using standard methods. The antimicrobial activity of the plant extract was examined against 2 bacterial strains among one is gram positive and other is gram negative and 2 fungal strains using agar well diffusion method.Results: The present investigation shows the phytochemical analysis, antimicrobial activity of the ethanolic extract of the plant Leucas Plukenetii Spreng. Various phytochemical analyses revealed the presence of alkaloids, saponin, flavonoids, carbohydrates, glycosides, Steroids, proteins and amino acids and tannins. The antimicrobial activity of the ethanolic extract of the plant showed significant result against all the of the test organisms. Conclusion:The present study concluded that ethanolic extract of whole aerial parts of the Leucas Plukenetii Spreng contains the high presence of phytochemicals. The ethnaolic extract of the plant was found to possess promising antimicrobial activity when compared with the standards.

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“…Chemical investigations on chewing sticks and other medicinal plants reported to have medicinal properties has also generated numerous purified compounds which have proven to be essential in the practice of modern medicine (Ncube et al, 2012). The use of teeth cleaning agents like tooth brush and tooth pastes or chewing sticks varies from country to country, from urban to rural areas and culture to culture.…”

Section: Introductionmentioning

confidence: 99%