In Vitro Antioxidant and Antimicrobial Activities of Mondia whitei (Hook. f.) Skeels

Abstract

Mondia whitei (Periplocaceae)is an aromatic plant used as aphrodisiac and for the treatment of urinary infection, jaundice, headache and diarrhoea in Nigeria. The plant was screened for phytochemical components using standard techniques. The antioxidant and antimicrobial activities of the plant were evaluated. The free radical scavenging activity was determined by 2, 2-diphenyl-1-picryl hydrazyl (DPPH) assay. The antimicrobial activity of M. whitei extracts against nine clinical isolates was determined by agar well diffusion method. Data were statistically analysed. The root was richer in saponins and tannins than the leaf whereas the leaf contained more flavonoids. The root gave 47.23% inhibition against DPPH+. There was positive correlation between the polyphenolic content and the antioxidant activity of the plant parts. At 300mg/ml, the water extracts of both the leaf and root were more active than the ethanolic extracts. The higher antimicrobial activity of the water extract could be attributed to the solubility of active constituents of the plant in water. The root showed higher antioxidant and antimicrobial activities than the leaf. M. whitei root could be very effective in the management of metabolic and infectious diseases. However, toxicological studies will confirm its safety in administration.

Essential oil constituents and in vitro antimicrobial activity of the root of Mondia whitei (Hook. F.) Skeels (Periplocaceae)

“…However, the present study shows that the antimicrobial effect of the root oil against organisms conforms to previous reports on the anti-infective potential of the extracts of the plant (Gbadamosi and Erinoso, 2015;Okitoi et al, 2007;Fankam et al, 2011). When compared with the findings of Gbadamosi and Erinoso (2015), the antimicrobial (Neugebauer, 1993;Gbadamosi and Oyedele, 2012).…”

“…Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License been earlier reported (Gbadamosi and Erinoso, 2015). Although, the aromatic roots of the plant are extensively used in tropical Africa for therapeutic purposes, there is a dearth of information on its active compounds and bioactivities of such compounds.…”

Evaluation of the Antibacterial Activity of Lemon Fruit Juice, Mondia Whitei Ethanolic Extract, and Their Combination Against Streptococcus Mutans

“…The study evaluated the antibacterial activity of the PE against Streptococcus mutans and result obtained are in agreement with studies conducted by [9,12,13]. Lemon extracts and MCERBE exhibited potent inhibitory activity against a broad range of both gram positive and gram negative bacteria [9,12,13].…”

“…Earlier studies revealed that citrus lemon juice possesses potent antimicrobial activity and eating fresh lemon fruits in addition to taking their juice has been associated with overall gum health and protection from dental caries [9][10][11]. Mondia whitei is an aromatic softwood climber with pale greenish-white or cream owers and its roots have a vanilla-like scent [12]. Previous studies demonstrated that the Mondia whitei crude ethanolic root bark extract (MCERBE) is effective against several oral Streptococci like S. pyogenes, S. sobrinus, and S. mitis [13].…”

Mondia whitei, an African Spice Inhibits Mitochondrial Permeability Transition in Rat Liver

“…The NO may thereafter affect the neurotransmitter activity across the brain system, which may ultimately result in a decrease in total sperm output ( 26 ). As part of its cytoprotective effect, previous works have shown that extracts of Mondia whitei have antioxidant properties ( 27 , 28 ).…”