In Vitro Antioxidant evaluation and DNA binding ability of Ni(II), Co(II), Cu(II) and Zn(II) metal complexes containing bidentate Schiff base

Abstract

Abstract:In the present study, the antioxidant and DNA binding properties of Ni(II), Co(II), Cu(II)

In vitro biological and in silico screening of novel iron(iii) complexes for DNA-targeted antitumor drug component

“…The % inhibition of both ascorbic acid (Sigma-Aldrich) and complexes was calculated by using the following formula:Inhibition (%) = ( A c − A s / A c ) × 100where A c = absorbance reading of the control, A s = absorbance reading of the sample. 49,50 IC 50 values correspond to a sample concentration which is essential for scavenging half of all DPPH-free radicals.…”

“…Ascorbic acid and the sample mixture containing no complexes were employed as the reference standard and the control, respectively. 49 The following formula was used to calculate the reducing power:Reducing power (%) = ( A s − A c / A s ) × 100,where A s = absorbance reading of the sample, A c = absorbance reading of the control. 50…”

“…where A c = absorbance reading of the control, A s = absorbance reading of the sample. 49,50 IC 50 values correspond to a sample concentration which is essential for scavenging half of all DPPH-free radicals.…”

“…Ascorbic acid and the sample mixture containing no complexes were employed as the reference standard and the control, respectively. 49 The following formula was used to calculate the reducing power:…”

“…DPPH radical scavenging and total antioxidant activity methods have been widely used to determine antioxidant properties. 49,112 The IC 50 values found for the complexes and the natural antioxidant ascorbic acid are shown in Table 4. Measurements show that the Fe1 and Fe2 complexes have significant radical scavenging ability depending on the dose (*p o 0.05).…”