Since, ancient time medicinal plants have been using to treat various human ailments. Blood clotting causes various heart associated diseases like myocardial infarction, deep vein thrombosis and renal vein thrombosis. Thrombolytic drugs are being employed to lyse the thrombus (blood clot) formed in the arteries. The modern systems of medicines have certain limitations and serious consequences which can alter the normal hemostasis process. Herbal medicines are known for their safety and efficacy in treating diseases effectively without producing any untoward effects. The present review provides the medicinal importance of some plants as thrombolytic agents. The source for the present review was taken from literature survey carried through the findings from suitable keywords in databases, PubMed, Google Scholar and Web of Science and Scopus, etc. This review provides the detailed information on medicinal plants and phytochemical compounds as thrombolytic agents.