In vitro bioactivity and biocompatibility of lithium substituted 45S5 bioglass

Khorami, Mina; Hesaraki, Saeed; Behnamghader, Aliasghar; Nazarian, Hamid; Shahrabi, Sara Salehi

doi:10.1016/j.msec.2011.07.011

Cited by 80 publications

(41 citation statements)

References 36 publications

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“…The as-received powders were weighed and mixed to obtain three different formulations of lithium-containing bioactive glasses (Li-BGs) in 300 g batches of compositions shown in Table 1. The substitution of Na 2 O by Li 2 O was done on a wt.% basis rather than the more appropriate mol.% basis, to be able to compare results with those of a previous study [19]. The homogenized powders were melted in Pt crucibles at 1400°C for 1 h. These processing parameters were chosen following the mentioned study of Khorami et al [19].…”

Section: Methodsmentioning

confidence: 99%

“…A study investigating the effects of lithium in patients treated with lithium carbonate found that such treatment may enhance or preserve bone mass [18]. Recently, lithium substituted 45S5 Bioglass® with different concentrations of Li 2 O were investigated and increased proliferation rates and alkaline phosphatase activity of osteoblastic cells were reported [19]. Such preliminary results on melt-derived (glassy, amorphous) 45S5 BG samples motivated the present research to further investigate Li-doped 45S5 bioactive glass (Li-BG), focusing however, on sintered and crystallized structures relevant for scaffold fabrication by the foam replica method [20].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development and characterization of lithium-releasing silicate bioactive glasses and their scaffolds for bone repair

Miguez-Pacheco

Büttner

Maçon

et al. 2016

Journal of Non-Crystalline Solids

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development and characterization of lithium-releasing silicate bioactive glasses and their scaffolds for bone repair

Miguez-Pacheco

Büttner

Maçon

et al. 2016

Journal of Non-Crystalline Solids

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“…For release to be controlled, lithium must enter the silicate network. Khorami et al substituted up to 12 wt% of sodium for lithium in 45S5 Bioglass Ò (45 wt% SiO 2 ; 24.5 wt% Na 2 O, 24.5 wt% CaO and 6 wt% P 2 O 5 ) [9]. Although lithium did not seem to alter the glass structure, a low lithium content (3 and 7 wt%) inhibited the formation of hydroxyapatite on the glass upon immersion in SBF.…”

Section: Introductionmentioning

confidence: 99%

Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships

Maçon

Jacquemin

Page

et al. 2016

J Sol-Gel Sci Technol

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This work reports the synthesis of lithium-silicate glass, containing 10 mol% of Li 2 O by the sol-gel process, intended for the regeneration of cartilage. Lithium citrate and lithium nitrate were selected as lithium precursors. The effects of the lithium precursor on the sol-gel process, and the resulting glass structure, morphology, dissolution behaviour, chondrocyte viability and proliferation, were investigated. When lithium citrate was used, mesoporous glass containing lithium as a network modifier was obtained, whereas the use of lithium nitrate produced relatively dense glass-ceramic with the presence of lithium metasilicate, as shown by X-ray diffraction, 29 Si and 7 Li MAS NMR and nitrogen sorption data. Nitrate has a better affinity for lithium than citrate, leading to heterogeneous crystallisation from the mesopores, where lithium salts precipitated during drying. Citrate decomposed at a lower temperature, where the crystallisation of lithium-silicate crystal is not thermodynamically favourable. Upon decomposition of the citrate, a solid-state salt metathesis reaction between citrate and silanol occurred, followed by the diffusion of lithium within the structure of the glass. Both glass and glass-ceramic released silica and lithium ions in culture media, but release rate was lower for the glass-ceramic. Both samples did not affect chondrocyte viability and proliferation.Graphical Abstract

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“…Afterwards, the reaction of these calcium ions with PO 4 -3 contained in the liquid result in the precipitation of a calcium phosphate layer on the sample surface 30,31 .…”

Section: Compositionsmentioning

confidence: 99%

Improving the Radiopacity of Calcium Aluminate Cement Based Blends

et al. 2018

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The radiopacity of CAC-based compositions containing additives (ZnO, Ag and Bi 2 O 3 ) was evaluated by optical density measurements, cold crushing strength, apparent porosity, pore size distribution, in vitro apatite-formation ability (bioactivity) and cell viability. The bioactivity was assessed via pH and calcium concentration measurements in simulated body fluid (SBF) for samples previously treated or not with sodium silicate (SS) solution. The surface of the samples after treatment was analyzed by scanning electron microscopy, energy dispersive X-ray analysis and confocal Raman spectroscopy. Cell viability was evaluated by MTT and alkaline phosphatase (ALP) activity. Radiopacity results confirmed that compositions containing ZnO-Ag (25:1 wt%) and ZnO-Bi 2 O 3 (15:10 wt%) presented suitable values of radiopacity (> 3 mmAl). The identification of calcium and mainly phosphorus by EDX, highlighted the generation of an apatite-like layer on the compositions' surface after immersion in SBF or SBF/SS. CAC-blend containing 25 wt% ZnO, ZnO-Ag and ZnO-Bi 2 O 3 presented slightly lower cell viability compared to the positive control.

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In vitro bioactivity and biocompatibility of lithium substituted 45S5 bioglass

Cited by 80 publications

References 36 publications

Development and characterization of lithium-releasing silicate bioactive glasses and their scaffolds for bone repair

Development and characterization of lithium-releasing silicate bioactive glasses and their scaffolds for bone repair

Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships

Improving the Radiopacity of Calcium Aluminate Cement Based Blends

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