In-vitro Comparative Study of Different Brands of Metoclopramide Hydrochloride Tablets Marketed in Saudi Arabia

Abstract

: Metoclopramide hydrochloride (MCP) a derivative of paraminobenzoic acid, freely soluble drug, rapidly absorbed from the gastrointestinal tract and is used in the management of gastrointestinal disorders such as gastric stasis, gastroesophageal reflux and for the prevention of cancer chemotherapy induced emesis. Many different brands of MCP are available in Saudi Arabia. Objectives: The objective of present study was to evaluate the four brands of MCP 10mg tablets (Premosan, Primperan, Maxolon and Metoclopramide) purchased from the retail pharmacy outlet in Abha, Riyadh and Jeddah, Saudi Arabia to choose the best brand. Methods: The study was done by quality control tests on branded tablets like; weight variation, hardness, friability, hardness, disintegration and dissolution. The results of all marketed products complied with the official specifications. The best brand was chosen depended on the quality control results. Results: The results showed that all parameters MCP tablets are in accordance with the USP limits. All the tested four brands were bioequivalent and complying with the official tests for weight variation, friability, disintegration and dissolution tests. The friability test was within the specified limit. All formulations were disintegrated within 2-6 min. The percentage content of active ingredient of four brands of MCP tablets showed values within the monograph specifications (95-105%). Conclusion: All the four brands evaluated in the present work could be considered bio pharmaceutically equivalent and therefore, patients can safely switch from one brand to another when there is unavailability of particular brand.

Evaluation of Seven Different Brands of Metformin Hydrochloride Tablets Available in the Market in Gondar City, Ethiopia

“…Typically, oral tablets exhibit a hardness range of 4 to 10 kg according to non-official USP specifications. 28 The result of the hardness test in this study showed that all brands failed the non-official test with M1 having the least hardness of 15.325±0.82 Kg and M4 having the highest hardness of 23.588±1.91 Kg. ( Table 4 )…”