In vitro dissolution studies of uranium bearing material in simulated lung fluid

Sdraulig, Sandra; Franich, Rick; Tinker, Rick; Solomon, Sarah E.; O'Brien, R.S.; Johnston, Peter

doi:10.1016/j.jenvrad.2007.08.009

Cited by 19 publications

(10 citation statements)

References 8 publications

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“…Characterization of AFT‐SLN‐PTX‐pMS—In Vitro Release : To evaluate the in vitro release behavior of AFT and PTX from the AFT‐SLN‐PTX‐pMS, 10.0 mg of AFT and PTX‐loaded pMS were weighed precisely and dispersed in 6.0 mL mSLF, which contained 0.02% w/v DPPC, 0.2% w/v SDS, and 0.01% w/v NaN 3 , then incubated at a speed of 100 rpm in an air bath (37.0 ± 0.5 °C). The detailed information of mSLF is shown in Section S2 in the Supporting Information . At each predetermined measuring point (2, 4, 8, 12, 24, 48, 72, 120, 168, 240, and 336 h), 1.0 mL of supernatant was collected and withdrawn by centrifugation; And 20.0 µL centrifuged supernatants were used for HPLC analysis.…”

Section: Methodsmentioning

confidence: 99%

PLGA Porous Microspheres Dry Powders for Codelivery of Afatinib‐Loaded Solid Lipid Nanoparticles and Paclitaxel: Novel Therapy for EGFR Tyrosine Kinase Inhibitors Resistant Nonsmall Cell Lung Cancer

Yang

Huang

Jin-yuan

et al. 2019

Adv Healthcare Materials

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Combination therapy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR TKIs) with other chemotherapeutic agents is a feasible strategy to overcome resistance that often occurs after 9–13 months of EGFR TKIs administration in nonsmall cell lung cancer (NSCLC). In this study, a pulmonary microspheres system that codelivers afatinib and paclitaxel (PTX) is developed for treatment of EGFR TKIs resistant NSCLC. In this system, afatinib is loaded in stearic acid‐based solid lipid nanoparticles, then these nanoparticles and PTX are loaded in poly‐lactide‐co‐glycolide‐based porous microspheres. These inhaled microspheres systems are characterized including geometric particle size, drug encapsulation efficiency, morphology by scanning electron microscopy, specific surface area, in vitro drug release, and aerodynamic particle size. Cell experiments indicate that afatinib and PTX have a synergistic effect and the codelivery system shows a superior treatment effect in drug‐resistant NSCLC cells. The biocompatibility, pharmacokinetic, and tissue distribution experiments in Sprague–Dawley rats show that afatinib and PTX in the system can maintain 96 h of high lung concentration but low concentration in other tissues, with acceptable safety. These results demonstrate that this system may be a prospective delivery strategy for drug combination treatment in cancers developing resistance, especially drug‐resistant lung cancer.

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Section: Methodsmentioning

confidence: 99%

PLGA Porous Microspheres Dry Powders for Codelivery of Afatinib‐Loaded Solid Lipid Nanoparticles and Paclitaxel: Novel Therapy for EGFR Tyrosine Kinase Inhibitors Resistant Nonsmall Cell Lung Cancer

Yang

Huang

Jin-yuan

et al. 2019

Adv Healthcare Materials

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“…Following non-destructive solid-state speciation techniques, leaching experiments provide important data on particle characteristics and the links to solubility, particle weathering rates and remobilization potential for particle associated radionuclides (and metals (Sdraulig et al, 2008) or extracted sequentially using reagents of increasing displacement and dissolution power (Kennedy et al, 1997;Skipperud and Salbu, 2015). Alternatively, biotic leaching can be made utilizing biological fluids such as incubation with rumen liquids or particles can be given to animals as part of their feed.…”

Section: Size Distributionmentioning

confidence: 99%

Challenges associated with the behaviour of radioactive particles in the environment

Salbu

Kashparov

Lind

et al. 2018

Journal of Environmental Radioactivity

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A series of different nuclear sources associated with the nuclear weapon and fuel cycles have contributed to the release of radioactive particles to the environment. Following nuclear weapon tests, safety tests, conventional destruction of weapons, reactor explosions and fires, a major fraction of released refractory radionuclides such as uranium (U) and plutonium (Pu) were present as entities ranging from sub microns to fragments. Furthermore, radioactive particles and colloids have been released from reprocessing facilities and civil reactors, from radioactive waste dumped at sea, and from NORM sites. Thus, whenever refractory radionuclides are released to the environment following nuclear events, radioactive particles should be expected. Results from many years of research have shown that particle characteristics such as elemental composition depend on the source, while characteristics such as particle size distribution, structure, and oxidation state influencing ecosystem transfer depend also on the release scenarios. When radioactive particles are deposited in the environment, weathering processes occur and associated radionuclides are subsequently mobilized, changing the apparent K. Thus, particles retained in soils or sediments are unevenly distributed, and dissolution of radionuclides from particles may be partial. For areas affected by particle contamination, the inventories can therefore be underestimated, and impact and risk assessments may suffer from unacceptable large uncertainties if radioactive particles are ignored. To integrate radioactive particles into environmental impact assessments, key challenges include the linking of particle characteristics to specific sources, to ecosystem transfer, and to uptake and retention in biological systems. To elucidate these issues, the EC-funded COMET and RATE projects and the IAEA Coordinated Research Program on particles have revisited selected contaminated sites and archive samples. This COMET position paper summarizes new knowledge on key sources that have contributed to particle releases, including particle characteristics based on advanced techniques, with emphasis on particle weathering processes as well as on heterogeneities in biological samples to evaluate potential uptake and retention of radioactive particles.

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“…Gamble’s solution, at acidic and neutral pH, has been developed for the testing of environmental particles (for instance: (Wragg & Klinck, 2007 ; Colombo et al., 2008 ; Sdraulig et al., 2008 ; Gray et al., 2010 ; Julien et al., 2011 )). The acidic pH should mimic the situation in lysosomes of AMs and IMs, while the neutral pH should represent the interstitial fluid.…”

Section: In Vitro Testingmentioning

confidence: 99%

Toxicity of orally inhaled drug formulations at the alveolar barrier: parameters for initial biological screening

Frőhlich

2017

Drug Delivery

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To cite this article: Eleonore Fröhlich (2017) Toxicity of orally inhaled drug formulations at the alveolar barrier: parameters for initial biological screening, Drug Delivery Oral delivery is the most common mode of systemic drug application. Inhalation is mainly used for local therapy of lung diseases but may also be a promising route for systemic delivery of drugs that have poor oral bioavailability. The thin alveolar barrier enables fast and efficient uptake of many molecules and could deliver small molecules and proteins, which are susceptible to degradation and show poor absorption by oral application. The low rate of biotransformation and proteolytic degradation increases bioavailability of drugs but accumulation of not absorbed material may impair normal lung function. This limitation is more relevant for compounds that should be systematically active because higher doses have to be applied to the lung. The review describes processes that determine absorption of orally inhaled formulations, namely dissolution in the lung lining fluid and uptake and degradation by alveolar epithelial cells and macrophages. Dissolution testing in simulated lung fluid, screening for cytotoxicity and pro-inflammatory action in respiratory cells and study of macrophage morphology, and phagocytosis can help to identify adverse effects of pulmonary formulations. ARTICLE HISTORY

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In vitro dissolution studies of uranium bearing material in simulated lung fluid

Cited by 19 publications

References 8 publications

PLGA Porous Microspheres Dry Powders for Codelivery of Afatinib‐Loaded Solid Lipid Nanoparticles and Paclitaxel: Novel Therapy for EGFR Tyrosine Kinase Inhibitors Resistant Nonsmall Cell Lung Cancer

PLGA Porous Microspheres Dry Powders for Codelivery of Afatinib‐Loaded Solid Lipid Nanoparticles and Paclitaxel: Novel Therapy for EGFR Tyrosine Kinase Inhibitors Resistant Nonsmall Cell Lung Cancer

Challenges associated with the behaviour of radioactive particles in the environment

Toxicity of orally inhaled drug formulations at the alveolar barrier: parameters for initial biological screening

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