In Vitro Dissolution Study of Glimepiride From Binary and Ternary Solid Dispersion Formulation

Abstract

Glimepiride (GMP) is poorly water soluble drug, so solubility is the main constraint for its oral bioavailability. Because, poor aqueous solubility and slow dissolution rate of the glimepiride lead to irreproducible clinical response or therapeutic failure in some cases due to sub therapeutic plasma drug levels. In this study, binary and ternary solid dispersion of glimepiride were prepared with polyethylene glycol 6000 (PEG 6000) and polyethylene glycol 4000 (PEG 4000) at different weight ratios using the solvent evaporation and melting method. It was found the drug was released 0.46% after 5 minutes and only 15.83% within 60 minutes from active glimepiride on the other hand the release pattern of glimepiride from the binary formulation containing PEG 4000 in 1:5 (Formulation coding: G5) showed the best result. It was found that the ternary different SD formulation containing(PEG4000:Glimepiride:Povidone) In ratio 1:1:0.25 (Formulation coding were : G13) showed the best result. The drug was changed to amorphous form after solid dispersion. Itwas also evident that solid dispersions improve solubility of drug particles thus enhancing dissolution characteristics of drugs they increase the oral bioavailability.
 Peer Review History: 
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 Received file 
 
 Average Peer review marks at initial stage: 4.5/10
 Average Peer review marks at publication stage: 7.5/10
 Reviewer(s) detail:
 Name: Dr. Mohammed Abdel-Wahab Sayed Abourehab 
 Affiliation: Umm Al-Qura University; Makkah Al-Mukarramah, Saudi Arabia
 E-mail: maabourehab@uqu.edu.sa
 
 Name: Dr. Evren Alğin Yapar
 Affiliation: Turkish Medicines and Medical Devices Agency, Turkiye
 E-mail: evren.yapar@yahoo.com
 Comments of reviewer(s): 

Preparation, Physicochemical Characterization and In-Vitro Dissolution Studies of Ketoprofen Solid Dispersion with PEG 6000 and HPMC 6 cps

“…The solidified mixture was ground by using a mortar and pestle and passed through the sieve (mesh size 40) to get solid dispersions. Finally, the resulting samples (SDs) were weighed and transferred in fresh glass vials with proper labeling and stored in a desiccator until further use (Islam et al, 2019).…”

Solid Dispersion: Solubility Enhancement Technique of Poorly Water Soluble Drug

“…Hot melt extrusion method: In this method extruder is utilized for intense mixing of components. Physical mixture of both the drug and carrier is introduced into the hopper then passed through screw and finally it is extruded from the die [18].…”